Kibuli Secondary School (KSS) is a mixed boarding secondary school in Uganda.

KSS is located on Kibuli Hill, in Makindye Division, in the south-central part of the city of Kampala, Uganda's capital and largest city. The coordinates of Kibuli Secondary School are:0°18'38.0"N, 32°35'51.0"E (Latitude:0.310556; Longitude:32.597500).

The school is affiliated with the Muslim faith, but admission is based on academic performance and is open to any interested student, regardless of religious beliefs. The school has a reputation of being a leading academic center with a history of sporting achievements.

Prince Badru Kakungulu, a Buganda Royal, who lived during the early 20th Century, donated 80 acres (32 ha) on Kibuli Hill, where the school was constructed. The school was founded in 1959.

The following are some of the prominent people who have gone through the school:

• Nancy Kacungira - Journalist, reporter and presenter at BBC on Focus on Africa and World Business Report
• Hakim Sendagire - Physician, microbiologist, biochemist and academic administrator. Current Dean, Habib Medical School
• John Ssebaana Kizito - Former Mayor of Kampala
• Moses Matovu, musician
• Henry Tumukunde - Former Director, Internal Security Organization (ISO)
• Muhammad Nsereko - Member of the Parliament of Uganda for Kampala Central.
• Ssekaana Musa - Justice of the High court of Uganda.
• Moses Muhangi - President of Uganda Boxing Federation
• Sarah Kanyike - Cabinet Minister for the elderly and disabled, effective July 2020.

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