Killer Creek is a creek in the Moira River and Lake Ontario drainage basins in Addington Highlands, Lennox and Addington County, Ontario, Canada.

Killer Creek begins at an unnamed lake at an elevation of 344 metres (1,129 ft) and flows southwest to Killer Lake at an elevation of 328 metres (1,076 ft). It then heads generally south to reach its mouth at the west end of Skootamatta Lake on the Skootamatta River at an elevation of 289 metres (948 ft). The Skootamatta River flows via the Moira River to the Bay of Quinte on Lake Ontario at Belleville.

• List of rivers of Ontario