Killhope Cross (elevation 627 m; 2,057 ft) is a mountain pass in the English Pennines. The pass divides Weardale to the east and Cumbria to the west. The road over the pass, the (A689) from Hartlepool to Carlisle, Cumbria, connects the hamlet of Cornriggs in County Durham with the town of Alston, Cumbria. It is the equal highest paved pass in England with the Harthope Moss approximately 10 miles (16 km) to the south, on the other side of Burnhope Seat (747 m; 2,451 ft).

The pass is named for a Grade-II-listed boundary cross at the highest point of the pass, described as "of uncertain date but possibly medieval".

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