Kryzhopil (Ukrainian: Крижопіль; Russian: Крыжополь, romanized: Kryzhopol) is a rural settlement in Tulchyn Raion, Vinnytsia Oblast, Ukraine. Before the 2020 reform, the settlement was the administrative centre of the former Kryzhopil Raion. Population: 8,479 (2022 estimate).

Kryzhopil was founded in 1866 during the construction of Kyiv-Odesa railroad and named after village Krzyżopol, located 17 km from the modern settlement. Railway station started to operate in August 1870. Since foundation to 1923 the settlement was a part of Olgopolsky Uyezd of Podolian Governorate.

During World War II, Kryzhopil was occupied by Romanian forces and became a part of Transnistria Governorate. The settlement was retaken by the Red Army on 17 March 1944.

Until 26 January 2024, Kryzhopil was designated urban-type settlement. On this day, a new law entered into force which abolished this status, and Kryzhopil became a rural settlement.

Notable people that were born or lived in Kryzhopil include:

• Sidor Belarsky (1898–1975), Ukrainian-American singer