Krzyżkowice [kʂɨʂkɔˈvit͡sɛ] is an Upper Silesian village in the administrative district of Gmina Lubrza, within Prudnik County, Opole Voivodeship, in south-western Poland, close to the Czech border. Historically located in Upper Silesia, in the Prudnik Land.

It lies approximately 6 kilometres (4 mi) south-east of Lubrza, 8 km (5 mi) south-east of Prudnik, and 46 km (29 mi) south-west of the regional capital Opole.