Kupang Regency is a regency in East Nusa Tenggara province of Indonesia. It occupies the far western end of Timor Island (apart from the area of Kupang city, which has been administratively separated from the Regency since 11 April 1996), together with the smaller island of Semau (off the southwestern tip of Timor) and other minor offshore islands (of which Kera is the only inhabited). Other islands further to the southwest and west which were formerly part of Kupang Regency have been separated administratively - the Rote Islands Group on 10 April 2002 (to form Rote Ndao Regency), and the Savu Islands Group on 29 October 2008 (to form Sabu Raijua Regency).

The residual regency covers an area of 5,668.26 square kilometres (2,188.53 sq mi). It had a population of 304,548 at the 2010 Census and 366,383 at the 2020 Census; the official estimate as at mid-2023 was 387,217.

The capital of Kupang Regency is at Oelamasi.

The regency is divided into twenty-four districts (kecamatan), tabulated below with their areas and their populations at the 2010 Census and the 2020 Census, together with the official estimates as at mid 2023. The districts are grouped geographically, and these groups have no administrative significance. The table also includes the locations of the district administrative centres, the number of administrative villages in each district (totaling 160 rural desa and 17 urban kelurahan), and its post code.

Kode Wilayah	Name of District (kecamatan)	English name	Area in km	Pop'n Census 2010	Pop'n Census 2020	Pop'n Estimate mid 2023	Admin centre	No. of desa	No. of kelu- rahan	Post code
53.01.04	Semau	Semau Island (North)	143.42	6,688	7,614	7,960	Uitao	8	-	85352
53.01.23	Semau Selatan	Semau Island (South)	140.18	4,731	5,396	6,078	Akle	6	-	85353
Totals	Semau Island	Semau Island	283.60	11,419	13,010	14,038		14	-
53.01.05	Kupang Barat	West Kupang	149.72	15,417	18,270	19,549	Batakte	10	2	85351
53.01.16	Nekamese		122.44	9,010	11,524	12,507	Oemasi	11	-	85390
53.01.08	Kupang Tengah	Central Kupang	94.79	33,805	45,709	45,075	Tarus	7	1	85361
53.01.24	Taebenu		104.44	14,594	18,166	18,138	Baumata	8	-	85360
53.01.09	Amarasi		155.09	15,279	17,881	19,533	Oekabiti	8	1	85367
53.01.17	Amarasi Barat	West Amarasi	205.12	14,375	16,846	17,668	Teunbaun	7	1	85376
53.01.18	Amarasi Selatan	South Amarasi	172.81	10,276	11,839	13,093	Buraen	3	2	85377
53.01.19	Amarasi Timur	East Amarasi	162.91	7,054	8,935	9,736	Pakubaun	4	-	85378
53.01.06	Kupang Timur	East Kupang	177.63	40,525	51,032	52,041	Babau	8	5	85362
53.01.20	Amabi Oefeto Timur	East Amabi Oefeto	420.24	13,059	13,277	15,468	Oemofa	10	-	85363
53.01.25	Amabi Oefeto	Amabi Oefeto	140.19	7,747	8,611	9,638	Fatuknutu	7	-	85362 & 85363
53.01.07	Sulamu		266.07	14,280	17,394	18,843	Sulamu	6	1	85368
Totals	Southern group		2,171.45	195,421	239,484	251,289		89	13
53.01.10	Fatuleu		400.29	23,007	26,849	28,629	Camplong	9	1	85371
53.01.28	Fatuleu Tengah	Central Fatuleu	99.50	4,885	5,736	6,247	Oelbiteno	4	-	85320
53.01.27	Fatuleu Barat	West Fatuleu	496.47	8,399	9,070	10,694	Poto	5	-	85323
53.01.11	Takari		655.79	20,262	24,566	25,896	Takari	9	1	85369
Totals	Fatuleu group		1,652.05	56,553	66,221	71,366		27	2
53.01.12	Amfoang Selatan	South Amfoang	278.34	8,628	10,003	10,411	Lelogama	6	1	85373
53.01.21	Amfoang Barat Daya	Southwest Amfoang	167.59	4,263	5,075	5,530	Manubelon	4	-	85364
53.01.30	Amfoang Tengah	Central Amfoang	203.47	5,397	6,410	6,911	Naikliu	4	-	85374
53.01.13	Amfoang Utara	North Amfoang	212.64	7,004	8,091	8,458	Soliu	5	1	85365
53.01.22	Amfoang Barat Laut	Northwest Amfoang	428.59	8,762	10,376	10,919	Nunuanah	6	-	85372
53.01.26	Amfoang Timur	East Amfoang	270.53	7,101	7,713	8,195	Fatumonas	5	-	85375
Totals	Amfoang group		1,561.16	41,155	47,668	50,424		30	2
	Totals		5,668.26	304,548	366,383	387,217	Oelamasi	160	17

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