La Plume is an unincorporated community in Lackawanna County, Pennsylvania, United States. The community is located at the intersection of U.S. Route 6 and Pennsylvania Route 438, 1.5 miles (2.4 km) east-southeast of Factoryville. La Plume has a post office with ZIP code 18440. La Plume is located 11 miles northwest of Scranton, one of Pennsylvania's most populous cities.