La Salle Street Bridge is a historic Spandrel Arch bridge located at South Bend, St. Joseph County, Indiana. It was built in 1907, and is a three-span, reinforced concrete bridge that crosses the St. Joseph River. It measures 279 feet long and 51 feet wide.

It was listed on the National Register of Historic Places in 1999. The previous bridge at this location is also listed on the register.