Le Haut-Saint-François (French pronunciation: [lə o sɛ̃ fʁɑ̃swa]; The Upper Saint-François [St. Francis]) is a regional county municipality in southeastern Quebec, Canada in the Estrie region. Its seat is in Cookshire-Eaton, and it is named for the Saint-François River which runs through the RCM.

There are 14 subdivisions within the RCM:

Mother tongue data, from Canada 2016 Census:

Language	Population	Pct (%)
French only	19,580	88.3%
English only	2,195	9.9%
Both English and French	205	0.9%
Other languages	200	0.9%

Highways and numbered routes that run through the municipality, including external routes that start or finish at the county border:

• List of regional county municipalities and equivalent territories in Quebec