Lee Drug is a historic commercial building located at 6800 W. Hollywood Boulevard and 1669 N. Highland Avenue in Hollywood, California. During its heyday, Lee Drug housed a drugstore that, due to its proximity to major Hollywood studios, sold a large selection of TV and screen make-up to actors. The building takes its name from this store.

Lee Drug synthesizes Art Deco and Streamline Moderne styles, and features horizontal banding, deco detailing, and a pronounced vertical sign projected above the roof.

Lee Drug was built by B. D. Bixby in 1935, and in 1985, when the Hollywood Boulevard Commercial and Entertainment District was added to the National Register of Historic Places, Lee Drug was listed as a contributing property in the district.

In 1993, Lee Drug and its neighboring building were sold for $18.9 million ($39.9 million in 2023).

In 2024, Lee Drug was one of four Hollywood and Highland buildings proposed for demolition to make way for a metro entrance on the K Line Northern Extension. The other buildings are 6806 Hollywood Boulevard, Bank of America Building, and Hollywood Theater.

• List of contributing properties in the Hollywood Boulevard Commercial and Entertainment District