Marsh Lane railway station was built as the Leeds terminus of the Leeds and Selby Railway. The combined passenger and goods station opened in 1834. During the construction of the extension of the Leeds and Selby Line into central Leeds in the 1860s the station was demolished, and replaced with a large goods station and a separate through passenger station.

In 2019, councillors at Leeds City Council suggested in the local media that serious discussions were underway about reopening the station as the city's second major railway station.

The station was built as the Leeds terminus of the Leeds and Selby Railway which opened in 1834. The first official train to run on the line started from Marsh Lane at around 6.30 am on 22 September 1834.

In 1842 the station consisted of a two-storey office building, containing a booking office on the ground floor, with the railway level with the first floor. The main station shed had four lines of track, serving both goods and passenger trains; the building was roofed and supported on cast iron columns. The passenger lines lacked raised platforms, unlike other stations on the line. Goods were handled at a warehouse at the west end of the station, adjacent to the offices, and at a supplementary building, added onto the northeast side of the original trainshed.

The station also included the railway's workshops in the northeast corner of the site, and coal and lime depots on the south side.

After the acquisition of the Leeds and Selby by the York and North Midland Railway (Y&NMR) in 1840 passenger trains were diverted via the Y&NMR's line to its station in Hunslet Lane station. A local passenger service to Milford Junction was started in 1850.

Around 1863 the site at Marsh Lane was redeveloped into a goods station. The old station was demolished and a six-storey grain warehouse was constructed on the site, designed by architect Thomas Prosser. In 1869 the North Eastern Railway's (NER) Leeds extension line from Marsh Lane to Leeds New railway station was completed, allowing through running along the Leeds and Selby Line into Leeds and beyond. A new passenger station was constructed at Marsh Lane on the route into central Leeds.

In 1894 an expansion of the facilities at the station was completed.

Preceding station	Historical railways			Following station
Leeds Line and station open		North Eastern Railway		Osmondthorpe Line open, station closed

The station was closed in 1958. The Prosser grain warehouse was burnt down by a fire in the 1970s. As of 2013 the site was being offered for redevelopment by London and Continental Railways.

Discussions about Leeds' rail network began in the 1990s with proposals to build a tram network. Marsh Lane and the nearby dual carriageway were considered as sites for stops to expand the city centre outwards St James's University Hospital. The Leeds Supertram proposal was rejected, meaning Leeds continued to operate with a single city centre light rail station. As development began in nearby Quarry Hill, Leeds when the Department of Health located their new headquarters backing onto Marsh Lane. The nearby area over the next decade saw the construction of Leeds City College and other gentrification to the east of Leeds.

This development, along with the city's reliance on Leeds City train station, led many to publicly call for a second city centre railway station. Leeds City Council told local media in February 2020 that the reopening of Marsh Lane railway station should be seriously considered.

• Leeds Central railway station and Holbeck railway station, also closed in the 1950/60s

• Whishaw, Francis (1842), The Railways of Great Britain and Ireland Practically Described and Illustrated (2nd ed.), alt link
• Tomlinson, William Weaver (1915), The North Eastern Railway; its rise and development, Andrew Reid and Company, Newcastle; Longmans, Green and Company, London
• Brees, Samuel (1838), Railway practice (2nd ed.), alt link, alt link
• Fawcett, Bill, ed. (2001), A History of North Eastern Railway Architecture, vol. 1, North Eastern Railway Association
• Hoole, Ken (1986), A regional history of the railways of Great Britain. Vol 4, The North East (3rd ed.), David and Charles

• "Leeds: Marsh Lane Station. 1961", www.flickr.com