Leipzig-Plagwitz (German: Bahnhof Leipzig-Plagwitz) is a railway station located in Leipzig, Germany. The station opened on 20 October 1873. The station is located on the Leipzig–Probstzella railway, Leipzig-Plagwitz–Markkleeberg-Gaschwitz railway and Leipzig-Plagwitz–Leipzig Miltitzer Allee railway. The train services are operated by Deutsche Bahn and Erfurter Bahn. Since December 2013 the station is served by the S-Bahn Mitteldeutschland. As part of this, the platforms in Leipzig-Plagwitz had been moved directly north to Karl-Heine-Straße and received new entrances.

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