The Lewis Kayton House, also known as the Mansion on Forsyth Park, is a historic five-star hotel at 700 Drayton Street in Savannah, Georgia, United States. It is significant as it was once the home of Lewis Kayton, an early pioneer to Savannah in the 19th century. The hotel occupies the Drayton block of Forsyth Park and is part of the Savannah Historic District. The hotel is now owned by hotel developer Richard C. Kessler, chairman and CEO of The Kessler Enterprise, Inc.

The Lewis Kayton House was built, of brick and terracotta, between 1888 and 1889, to designs by architects Alfred Eichberg and Hyman Witcover for Lewis Kayton, a businessman from Baltimore, Maryland. The cost was $45,000 (equivalent to $1,526,000 in 2023).

The house changed hands several times. It became the Fox & Weeks funeral home in 1953, which was in business for over fifty years.

Today, the Lewis Kayton House, also known as Mansion on Forsyth Park, is a 126-room Romanesque Revival-style hotel which covers 18,000 square feet (1,700 m). The former Kayton mansion was converted into a lounge and restaurant that includes a cooking school. The three-story hotel was built onto the mansion with the same exterior style. There is an art gallery and outdoor patio with a pool. The hotel is owned and managed by The Kessler Enterprise, Inc.

• List of hotels in the United States
• List of National Historic Landmarks in Georgia (U.S. state)
• National Register of Historic Places listings in Georgia
• Buildings in Savannah Historic District