Puerto Rico currently has the fourth-most active players in Major League Baseball (MLB) among Latin American jurisdictions, behind the Dominican Republic, Venezuela and Cuba. More than three hundred players from the archipelago have played in the major leagues since 1926. This includes players who were born in either one of the archipelago's islands and those of Puerto Rican heritage. Only those players who have worked in the major leagues are listed, not those active in the minor leagues, nor negro independent leagues.

For years, it was considered that the first player from Puerto Rico to play in the major leagues was Hiram Bithorn in 1942. But this changed in December 2020, when seven Negro baseball leagues between 1920 and 1948 were recognized as "major leagues." Thus, the first Puerto Rican to play baseball on the major leagues was Jose "Gacho" Torres, who debuted in 1926.

After the baseball color line was abandoned following Jackie Robinson's debut in the National League of MLB, more players from the island signed contracts. This led to an improvement in their performance, and some of them were selected to participate in the Major League Baseball All-Star Game. Including their names in the Major League Baseball draft is a requisite for first-year players born in Puerto Rico, because the league recognizes the island as a jurisdiction within the United States. Following the implementation of this measure, Puerto Rico's government requested exclusion from the draft and help to develop players, in order to reduce the impact of the change in the format of talent development.

Baseball was introduced to Puerto Rico by immigrants during the nineteenth century. The first sanctioned baseball game in the island was played on January 9, 1898, in Santurce, Puerto Rico, where two teams composed of Puerto Rican, American and Cuban players participated. After this game, baseball became a widespread sport and professional and amateur leagues were organized. During this time period, the Puerto Rico national teams experienced success on international competition and Afro-Puerto Rican players began to participate in the Negro leagues.

Hiram Bithorn debuted as a pitcher with the Chicago Cubs on April 15, 1942, but before him, there were about 10 other players who worked on the negro leagues, now considered as major leagues. About 17 other Puerto Rican players in the negro leagues were active right before the introduction of African American players in Major League Baseball, and thus, there were more chances to players born in the island. Subsequently, Afro-Puerto Rican players such as Orlando Cepeda and Victor Pellot Power began having solid performances in the league, and were selected to participate in the Major League Baseball All-Star Game. In 1973, Roberto Clemente became the first player from Puerto Rico and first Latin American to be elected as a member of the National Baseball Hall of Fame and Museum. Since then Puerto Rico has kept a stable number of players in the league. During this timeframe, several players have been selected to participate in the All-Star Game or won awards for their performance, while others imposed records within the league. These include Javy López, who holds the record for most home runs hit by a catcher in a single season. Both Iván Rodríguez and Roberto Alomar hold the record for most Gold Glove Awards in their positions. Recipients of the Most Valuable Player Award include Orlando Cepeda, Juan González and Iván Rodríguez. Roberto Clemente and Mike Lowell also won the World Series MVP Award in their respective divisions. Carlos Delgado is the only Latin to hit 4 homers in a game.

Originally, players who were either born or naturalized in Puerto Rico were able to sign with MLB teams as free agents, usually receiving minor-league contracts prior to their debut in the league. In 1989, Major League Baseball decided to include the island in the list of jurisdictions within the United States, which made mandatory that first-year players include their name in the Major League Baseball Draft in order to receive a contract. This was based on an initiative that was supposed to create a national and international drafting system. The change reduced the number of players that were able to participate in the league, by limiting the number of them selected by the teams; this led to the island's Secretary of Recreation and Sports, to formally ask to Major League's involvement in developing specialized schools to produce more players and other measures to reduce the impact of the draft's implementation. The original proposal included Puerto Rico's exclusion of the draft for a period of ten years, but this was not approved by the league.

Puerto Rico was one of sixteen teams to participate in the inaugural edition of the World Baseball Classic. The tournament was created by Major League Baseball, the Major League Baseball Players Association, and other professional baseball leagues and their players associations around the world, including the Puerto Rican Professional Baseball League. The first event was organized in 2006, and was sanctioned by the International Baseball Federation. Puerto Rico won the silver medal on both 2013 and 2017 classics. The Hiram Bithorn Stadium in San Juan, Puerto Rico hosted 22 Montreal Expos home games in 2003, after the league decided to relocate the team to San Juan as part of an experiment to "globalize" baseball. During the series there was an average attendance of 14,222.

This list includes players born in Puerto Rico and players born outside of Puerto Rico to a Puerto Rican parent.

Name	Debut team	Years active	Reference
Juan Agosto	Chicago White Sox	1981–1993
Luis Aguayo	Philadelphia Phillies	1980–1989
Jonathan Albaladejo	Washington Nationals	2007–2012
José Alberro	Texas Rangers	1995–1997
Luis Alcaraz	Los Angeles Dodgers	1967–1970
Luis Alicea	St. Louis Cardinals	1988–2002
Sandy Alomar Jr.	San Diego Padres	1988–2007
Sandy Alomar Sr.	Milwaukee Braves	1964–1978
Roberto Alomar	San Diego Padres	1988–2004
Luis Alvarado	Boston Red Sox	1968–1977
Orlando Álvarez	Los Angeles Dodgers	1973–1976
Robert Andino	Florida Marlins	2005–2013
Luis Aquino	Toronto Blue Jays	1986–1995
Jake Arrieta	Baltimore Orioles	2010–2022
Christian Arroyo	San Francisco Giants	2017–present
Luis Arroyo	St. Louis Cardinals	1955–1963
Rudy Arroyo	St.Louis Cardinals	1971
Luis Atilano	Washington Nationals	2010
Mike Avilés	Kansas City Royals	2011–2017
Ramón Avilés	Boston Red Sox	1977–1981
Benny Ayala	New York Mets	1974–1985
Carlos Baerga	Cleveland Indians	1990–2005
Javier Báez	Chicago Cubs	2014–present
Kevin Baez	New York Mets	1990–1993
Aaron Bates	Boston Red Sox	2009
Carlos Beltrán	Kansas City Royals	1998–2017
Juan Beníquez	Boston Red Sox	1971–1987
Yamil Benítez	Montreal Expos	1995–1998
Jonathan Bermúdez	Miami Marlins	2024
Tony Bernazard	Montreal Expos	1979–1991
Carlos Bernier	Pittsburgh Pirates	1953
José Berríos	Minnesota Twins	2016–present
Hiram Bithorn	Chicago Cubs	1942–1947
Hiram Bocachica	Los Angeles Dodgers	2000–2007
Ricky Bones	San Diego Padres	1991–2001
Bobby Bonilla	Chicago White Sox	1986–2001
Juan Bonilla	San Diego Padres	1981–1987
Hiram Burgos	Milwaukee Brewers	2013
Fernando Cabrera	Cleveland Indians	2004–2010
Luis Cabrera	Indianapolis Clowns	1948
Ivan Calderón	Seattle Mariners	1984–1993
Kiko Calero	St. Louis Cardinals	2003–2009
Luis Campusano	San Diego Padres	2020–2021
Robinson Cancel	Milwaukee Brewers	1999–2011
John Candelaria	Pittsburgh Pirates	1975–1993
John Cangelosi	Chicago White Sox	1985–1999
Víctor Caratini	Chicago Cubs	2017–present
Javier Cardona	Detroit Tigers	2000–2002
Rafael Carmona	Seattle Mariners	1995–1999
Raúl Casanova	Detroit Tigers	1996–2009
Ramón Castro	Florida Marlins	1999–2011
Willi Castro	Detroit Tigers	2019–2021
Xavier Cedeño	Washington Nationals	2011–2019
Juan Centeno	New York Mets	2013–2019
Orlando Cepeda	San Francisco Giants	1958–1974
Leonardo Chapman	Baltimore Elite Giants	1944
Alex Cintrón	Arizona Diamondbacks	2001–2010
Alex Claudio	Texas Rangers	2014–2021
Edgard Clemente	Colorado Rockies	1998–2000
Roberto Clemente	Pittsburgh Pirates	1955–1972
Jaime Cocanower	Milwaukee Brewers	1983–1986
Pancho Coimbre	New York Cubans	1940–1944
Willie Collazo	New York Mets	2007
Christian Colón	Kansas City Royals	2014–2020
Joe Colón	Cleveland Indians	2016
Monchile Concepción	Phila. Bacharach Giants	1934
Onix Concepción	Kansas City Royals	1980–1987
Ramón Conde	Chicago White Sox	1962
Alex Cora	Los Angeles Dodgers	1998–2011
Joey Cora	San Diego Padres	1987–1998
Wil Cordero	Montreal Expos	1992–2005
Carlos Corporán	Houston Astros	2009–2015
Carlos Correa	Houston Astros	2015–present
Edwin Correa	Chicago White Sox	1985–1987
Fernando Cortez	Tampa Bay Devil Rays	2005–2007
Henry Cotto	Chicago Cubs	1984–1993
César Crespo	San Diego Padres	2001–2004
Felipe Crespo	Toronto Blue Jays	1996–2001
Fernando Cruz	Cincinnati Reds	2022
Héctor Cruz	St. Louis Cardinals	1973–1982
Henry Cruz	Los Angeles Dodgers	1975–1978
Julio Cruz	Seattle Mariners	1977–1986
Iván Cruz	New York Yankees	1997–2002
José Cruz	St. Louis Cardinals	1970–1988
José Cruz Jr.	Seattle Mariners	1997–2008
Cirilo "Tommy" Cruz	St. Louis Cardinals	1973–1977
Noel Cuevas	Colorado Rockies	2018–2019
David DeJesus	Kansas City Royals	2003–2015
José DeJesús	Kansas City Royals	1988–1994
Iván DeJesús	Los Angeles Dodgers	1974–1988
Iván DeJesús Jr.	Los Angeles Dodgers	2011–2016
José De La Torre	Boston Red Sox	2013
José De León	Los Angeles Dodgers	2016–2021
Luis DeLeón	St. Louis Cardinals	1981–1989
Carlos Delgado	Toronto Blue Jays	1993–2009
Felle Delgado	New York Cubans	1941
Puchy Delgado	Seattle Mariners	1977
Alex Díaz	Milwaukee Brewers	1992–1999
Alexis Díaz	Cincinnati Reds	2022
Carlos Diaz	Atlanta Braves	1982–1986
Edgar Díaz	Milwaukee Brewers	1986–1990
Edwin Díaz	Arizona Diamondbacks	1998–1999
Edwin Díaz	New York Mets	2016–present
Isan Díaz	Miami Marlins	2019–2020
Jonathan Diaz	Boston Red Sox	2013–2015
Mario Díaz	Seattle Mariners	1987–1995
Mike Díaz	Chicago Cubs	1983–1988
Angel Echevarría	Colorado Rockies	1996–2002
Christian Encarnacion-Strand	Cincinnati Reds	2023
Nino Escalera	Cincinnati Redlegs	1954
José Espada	San Diego Padres	2023

Name	Debut team	Years active	Reference
Irving Falú	Kansas City Royals	2012–2014
Johneshwy Fargas	New York Mets	2021
Jesús Feliciano	New York Mets	2010
Mario Feliciano	Milwaukee Brewers	2021
Pedro Feliciano	New York Mets	2002–2013
Coco Ferrer	Indianapolis Clowns	1946–1948
Sergio Ferrer	Minnesota Twins	1974–1979
Ed Figueroa	California Angels	1974–1981
Luis Figueroa	Pittsburgh Pirates	2001–2007
Nelson Figueroa	Arizona Diamondbacks	2000–2011
Tite Figueroa	Baltimore Elite Giants	1946
Tito Figueroa	New York Cubans	1940
Gil Flores	California Angels	1977–1979
Jose Flores	Oakland Athletics	2002–2004
Miguel Fuentes	Seattle Pilots	1969
Rey Fuentes	San Diego Padres	2013–2017
Jason Garcia	Baltimore Orioles	2015
Pedro García	Milwaukee Brewers	1973–1977
Rico Garcia	Colorado Rockies	2019–2020
Mychal Givens	Baltimore Orioles	2015–present
Leo Gómez	Baltimore Orioles	1990–1996
Rubén Gómez	New York Giants	1953–1962
Andy González	Chicago White Sox	2007–2009
Dicky Gonzalez	New York Mets	2001–2004
Fernando González	Pittsburgh Pirates	1972–1979
Juan González	Texas Rangers	1989–2005
Julio González	Houston Astros	1977–1983
Pedro González	New York Yankees	1963–1967
Raúl González	Chicago Cubs	2000–2004
Julio Gotay	St. Luis Cardinals	1960–1969
Rubén Gotay	Kansas City Royals	2004–2008
Riley Greene	Detroit Tigers	2022
Vaughn Grissom	Atlanta Braves	2022
Felix Guilbe	Baltimore Elite Giants	1946–1947
Juan Guilbe	New York Cubans	1940–1947
Edwards Guzmán	San Francisco Giants	1999–2003
José Guzmán	Texas Rangers	1985–1994
Von Hayes	Cleveland Indians	1981–1992
Darell Hernáiz	Oakland Athletics	2024
Jesús Hernáiz	Philadelphia Phillies	1974
Alex Hernández	Pittsburgh Pirates	2000–2001
Enrique Hernández	Miami Marlins	2014–present
José Hernández	Texas Rangers	1991–2006
Ramón Hernández	Atlanta Braves	1967–1977
Roberto Hernández	Chicago White Sox	1991–2007
Rudy Hernández	Washington Senators	1960–1961
Willie Hernández	Chicago Cubs	1977–1989
Orlando Isales	Philadelphia Phillies	1980
Josh James	Houston Astros	2018–present
Mike James	California Angels	1995–2002
A. J. Jiménez	Texas Rangers	2017
Joe Jiménez	Atlanta Braves	2017–present
Ricardo Jordan	Toronto Blue Jays	1995–1998
Marc Kroon	San Diego Padres	1995–2004
Coco Laboy	Montreal Expos	1969–1973
Alex Lange	Detroit Tigers	2021–present
Ricky Ledée	New York Yankees	1998–2007
José León	Baltimore Orioles	2002–2004
Carlos Lezcano	Chicago Cubs	1980–1981
Sixto Lezcano	Milwaukee Brewers	1974–1985
Frankie Librán	San Diego Padres	1969
José Lind	Pittsburgh Pirates	1987–1995
Francisco Lindor	New York Mets	2015–present
Art López	New York Yankees	1965
Felipe López	Toronto Blue Jays	2001–2011
Jack López	Boston Red Sox	2021
Javier López	Colorado Rockies	2003–2016
Javy López	Atlanta Braves	1992–2006
Jorge López	Milwaukee Brewers	2015–present
Luis Lopez	Los Angeles Dodgers	1990–1991
Luis López	San Diego Padres	1993–2005
Luis Lopez	Toronto Blue Jays	2001–2004
Raffy Lopez	Chicago Cubs	2014–2018
Mike Lowell	Boston Red Sox	1998–2010
Willie Lozado	Milwaukee Brewers	1984
Seth Lugo	New York Mets	2016–present

Name	Debut team	Years active	Reference
Vimael Machin	Oakland Athletics	2020–2021
Anthony Maldonado	Miami Marlins	2024
Candy Maldonado	Los Angeles Dodgers	1981–1995
Martín Maldonado	Milwaukee Brewers	2011–present
Ángel Mangual	Pittsburgh Pirates	1969–1976
Pepe Mangual	Montreal Expos	1972–1977
Félix Mantilla Lamela	Milwaukee Braves	1956–1966
Robert Manuel	Cincinnati Reds	2009–2010
Luis Márquez	Homestead Grays	1946–1954
Oreste Marrero	Montreal Expos	1993–1996
Carmelo Martínez	Chicago Cubs	1983–1991
Dave Martínez	Chicago Cubs	1986–2001
Edgar Martínez	Seattle Mariners	1987–2004
Javier Martínez	Pittsburgh Pirates	1998
Ozzie Martínez	Florida Marlins	2010–2011
Ramón Martínez	San Francisco Giants	1998–2009
Damon Mashore	Oakland Athletics	1996–1998
Julius Matos	San Diego Padres	2002–2003
Luis Matos	Baltimore Orioles	2000–2006
Edwin Maysonet	Houston Astros	2008–2012
Francisco Meléndez	Philadelphia Phillies	1984–1989
José Meléndez	Seattle Mariners	1990–1994
Luis Meléndez	St. Louis Cardinals	1970–1977
MJ Melendez	Kansas City Royals	2022–present
Héctor Mercado	Cincinnati Reds	2000–2003
Orlando Mercado	Seattle Mariners	1982–1990
Orlando Merced	Pittsburgh Pirates	1990–2003
Félix Millán	Atlanta Braves	1966–1977
Ángel Miranda	Milwaukee Brewers	1993–1997
José Miranda	Minnesota Twins	2022–present
Bengie Molina	Anaheim Angels	1998–2010
José Molina	Chicago Cubs	1999–2014
Yadier Molina	St. Louis Cardinals	2004–2022
Johnny Monell	San Francisco Giants	2013–2015
Rafael Montalvo	Houston Astros	1986
Lou Montañez	Baltimore Orioles	2008–2011
Willie Montañez	California Angels	1966–1982
Charlie Montoyo	Montreal Expos	1993
Dan Monzon	Minnesota Twins	1972–1973
Jerry Morales	San Diego Padres	1969–1983
José Morales	Minnesota Twins	2007–2011
José Morales	Oakland Athletics	1973–1984
Jovani Moran	Minnesota Twins	2021
Roger Moret	Boston Red Sox	1970–1978
Steven Moya	Detroit Tigers	2014–2016
Manny Muñiz	Philadelphia Phillies	1971
Jose Munoz	Chicago White Sox	1996
Bobby Muñoz	New York Yankees	1993–2001
Pedro Muñoz	Minnesota Twins	1990–1996
Bob Natal	Montreal Expos	1992–1997
Brian Navarreto	Miami Marlins	2020
Jaime Navarro	Milwaukee Brewers	1989–2000
Julio Navarro	Los Angeles Angels	1962–1970
Millito Navarro	Cuban Stars East	1928–1929
Rey Navarro	Baltimore Orioles	2015
Tito Navarro	New York Mets	1993
Kristopher Negrón	Cincinnati Reds	2012–2019
Tomás Nido	New York Mets	2017–present
Juan Nieves	Milwaukee Brewers	1986–1988
Melvin Nieves	Atlanta Braves	1992–1998
Wil Nieves	San Diego Padres	2002–2015
Rafael Novoa	San Francisco Giants	1990–1993
Edwin Núñez	Seattle Mariners	1982–1994
Ed Olivares	St. Louis Cardinals	1960–1961
Omar Olivares	St. Louis Cardinals	1990–2001
Francisco Oliveras	Minnesota Twins	1989–1992
Luis Rodríguez Olmo	Brooklyn Dodgers	1943–1951
José Oquendo	New York Mets	1983–1995
Danny Ortiz	Pittsburgh Pirates	2017
Héctor Ortiz	Kansas City Royals	1998–2002
José Ortiz	Chicago White Sox	1969–1971
Junior Ortíz	Pittsburgh Pirates	1982–1994
Rafaelito Ortiz	Chicago American Giants	1948
Ricky Otero	New York Mets	1995–1997
Jorge Padilla	Washington Nationals	2009
Juan Padilla	New York Yankees	2004–2005
Nicholas Padilla	Chicago Cubs	2022
Ángel Pagán	Chicago Cubs	2006–2016
Emilio Pagán	San Diego Padres	2017–present
José Pagán	San Francisco Giants	1959–1973
Josh Palacios	Toronto Blue Jays	2021
Rey Palacios	Kansas City Royals	1988–1990
Richie Palacios	Cleveland Guardians	2022
Sam Parrilla	Philadelphia Phillies	1970
Victor Pellot	Philadelphia Athletics	1954–1965
Bert Peña	Houston Astros	1981–1987
Jim Pena	San Francisco Giants	1992
Luis Peraza	Philadelphia Phillies	1969
Jose Pereira	Baltimore Elite Giants	1947
Eduardo Perez	California Angels	1993–2006
Luis Pérez	Indianapolis Clowns	1948
Michael Pérez	Tampa Bay Rays	2018–present
Mike Pérez	St. Louis Cardinals	1990–1997
Roberto Pérez	Cleveland Indians	2014–present
Luis Pillot	New York Black Yankees	1941–43
Joel Piñeiro	Seattle Mariners	2000–2011
Juan Pizarro	Milwaukee Braves	1957–1974
Rafael Polanco	Newark Eagles	1941
Carlos Ponce	Milwaukee Brewers	1985
Simon Pond	Toronto Blue Jays	2004
Arnie Portocarrero	Philadelphia Athletics	1954–1960
Jorge Posada	New York Yankees	1995–2011
Luis Quiñones	Oakland Athletics	1983–1992
Rey Quiñones	Boston Red Sox	1986–1989
Tomás Quiñones	Indianapolis Clowns	1947
Luis Quintana	California Angels	1974–1975

Name	Debut team	Years active	Reference
Mario Ramírez	New York Mets	1980–1985
Milt Ramírez	St. Louis Cardinals	1970–1979
Heliot Ramos	San Francisco Giants	2022
Henry Ramos	Arizona Diamondbacks	2021, 2023
Vidal Richardson	Cleveland Buckeyes	1946
Alex Ríos	Toronto Blue Jays	2004–2015
Armando Ríos	San Francisco Giants	1998–2003
Edwin Ríos	Los Angeles Dodgers	2019–2021
Juan Ríos	Kansas City Royals	1969
Yacksel Ríos	Philadelphia Phillies	2017–2021
Bombo Rivera	Montreal Expos	1975–1982
Carlos Rivera	Pittsburgh Pirates	2003–2004
Charlie Rivera	Baltimore Elite Giants	1939–1944
Emmanuel Rivera	Kansas City Royals	2021–present
Germán Rivera	Los Angeles Dodgers	1983–1985
Jim Rivera	St. Louis Browns	1952–1961
Luis Rivera	Montreal Expos	1986–1998
Mike Rivera	Detroit Tigers	2001–2011
René Rivera	Seattle Mariners	2004–2021
Roberto Rivera	Chicago Cubs	1995–1999
Saúl Rivera	Washington Nationals	2006–2010
T.J. Rivera	New York Mets	2016–2017
Yadiel Rivera	Milwaukee Brewers	2015–2020
Benny Rodríguez	Chicago American Giants	1948
Dereck Rodríguez	San Francisco Giants	2018–present
Eduardo Rodríguez	Milwaukee Brewers	1973–1979
Edwin Rodríguez	New York Yankees	1982–1985
Ellie Rodríguez	New York Yankees	1968–1976
Frank Rodríguez	Boston Red Sox	1995–2001
Iván Rodríguez	Texas Rangers	1991–2010
John Rodríguez	St. Louis Cardinals	2005–2006
Johnathan Rodriguez	Cleveland Guardians	2024
José Rodríguez	St. Louis Cardinals	2000–2002
Steve Rodriguez	Boston Red Sox	1995
Tony Rodríguez	Boston Red Sox	1996
Victor Rodríguez	Baltimore Orioles	1984–1989
Ed Romero	Milwaukee Brewers	1977–1989
J. C. Romero	Minnesota Twins	1999–2012
Gil Rondón	Houston Astros	1976–1979
Jorge Roque	St. Louis Cardinals	1970–1973
Jose Rosado	Kansas City Royals	1996–2000
Luis Rosado	New York Mets	1977–1980
Eddie Rosario	Minnesota Twins	2015–present
Jimmy Rosario	San Francisco Giants	1971–1976
Santiago Rosario	Kansas City Athletics	1965
Dave Rosello	Chicago Cubs	1972–1981
Rico Rossy	Atlanta Braves	1991–1998
Chico Ruiz	Atlanta Braves	1978–1980
Randy Ruiz	Minnesota Twins	2008–2010
Ángel Sánchez	Kansas City Royals	2006–2013
Jonathan Sánchez	San Francisco Giants	2006–2013
Orlando Sánchez	St. Louis Cardinals	1981–1984
Rey Sánchez	Chicago Cubs	1991–2005
Benito Santiago	San Diego Padres	1986–2005
Carlos Santiago	New York Cubans	1946
Héctor Santiago	Chicago White Sox	2011–present
José "Pantalones" Santiago	New York Cubans	1948–1956
José "Palillo" Santiago	Kansas City Athletics	1963–1970
José Santiago	Kansas City Royals	1997–2005
Rafael Santo Domingo	Cincinnati Reds	1979
Ángel Santos	Boston Red Sox	2001–2003
Omir Santos	Baltimore Orioles	2008–2013
Candy Sierra	San Diego Padres	1988
Rubén Sierra	Texas Rangers	1986–2006
Jake Smith	San Diego Padres	2016
Ian Snell	Pittsburgh Pirates	2004–2010
Geovany Soto	Chicago Cubs	2005–2017
Giovanni Soto	Cleveland Indians	2015
Neftalí Soto	Cincinnati Reds	2013–2014
George Springer	Houston Astros	2014–present
Marcus Stroman	Toronto Blue Jays	2014–present
Danny Tartabull	Seattle Mariners	1984–1997
Valmy Thomas	New York Giants	1957–1961
Dickie Thon	California Angels	1979–1993
Andrés Torres	Detroit Tigers	2002–2013
Félix Torres	Los Angeles Angels	1962–1964
Gacho Torres	Newark Stars	1926
Rusty Torres	New York Yankees	1971–1980
Lou Trivino	Oakland Athletics	2018–present
Duane Underwood Jr.	Chicago Cubs	2018–present
Pedro Valdés	Chicago Cubs	1996–2000
Javier Valentín	Minnesota Twins	1997–2008
Jesmuel Valentín	Philadelphia Phillies	2018
John Valentin	Boston Red Sox	1992–2002
José Valentín	Milwaukee Brewers	1992–2007
Julio Valera	New York Mets	1990–1996
Héctor Valle	Los Angeles Dodgers	1965
Eddie Vargas	Pittsburgh Pirates	1982–1984
Kennys Vargas	Minnesota Twins	2014–2017
Roberto Vargas	Chicago American Giants	1948–1955
Christian Vázquez	Boston Red Sox	2014–present
Javier Vázquez	Montreal Expos	1998–2011
Luis Vázquez	Chicago Cubs	2024
Ramón Vázquez	Seattle Mariners	2001–2009
Jesús Vega	Minnesota Twins	1979–1982
Andrew Velazquez	Tampa Bay Rays	2018–present
Carlos Velázquez	Milwaukee Brewers	1973
Nelson Velázquez	Chicago Cubs	2022
Otto Vélez	New York Yankees	1973–1983
José Vidro	Montreal Expos	1997–2008
Mark Vientos	New York Mets	2022–present
Vicente Villafañe	Indianapolis Clowns	1947
Héctor Villanueva	Chicago Cubs	1990–1993
Ismael Villegas	Atlanta Braves	2000
Luis Villodas	Baltimore Elite Giants	1946–1947
Ozzie Virgil Jr.	Philadelphia Phillies	1980–1990
Bernie Williams	New York Yankees	1991–2006

• List of current Major League Baseball players by nationality

• "Welcome to Puerto Rico". ESPN. 2006-01-16. Archived from the original on 2006-06-14. Retrieved 2008-06-15.
• "A look at all of the Puerto Rican players who've played in MLB". MLB.com. 2018-04-17. Archived from the original on 2018-08-23. Retrieved 2018-08-23.
• "Major League Baseball Players Born in Puerto Rico / Played in 2017". baseball-almanac.com. Archived from the original on 2018-08-23. Retrieved 2018-08-23.