Barry Bonds hit numerous milestone home runs during his 22 seasons in Major League Baseball with the Pittsburgh Pirates and San Francisco Giants. Bonds ranks among the greatest baseball players of all time and was for much of his career considered a five-tool player. Bonds' ascension towards the top of experts' lists of greatest players was propelled by highly productive years in which he set many records. By 1998, he was considered among the 50 greatest players of all time by The Sporting News, and after winning the National League's Most Valuable Player Award four consecutive times from 2001–2004, he jumped into the top 10 in the 2005 list. He now holds numerous Major League Baseball records for home runs, bases on balls, intentional bases on balls, slugging percentage and on-base percentage, as well as a record seven MVP awards.

In baseball, the home run is one of the most popular aspects of the game. Thus, the career record for home runs is among the most important and respected records in baseball. The road to this record has been closely followed and each additional home run Bonds hits extends the current record further. On August 7, 2007, Barry Bonds became the major leagues' career home run champion by hitting his 756th career home run, which surpassed Hank Aaron's total.

Quite often milestone home runs such as round hundred and career records are considered breaking news, and sports news services give coverage to countdowns on impending milestone home runs. Several of Bonds' milestone home runs were given dedicated coverage on ESPN BottomLine, with Chasing Ruth and Chasing Aaron coverage being quite extensive for the few seasons preceding the breaking of the record. Sports collectible dealers and buyers pay exorbitant sums for paraphernalia associated with such milestones. The Baseball Hall of Fame covets such paraphernalia for display. In fact, players are even sensitive to the way in which their paraphernalia is displayed. A baseball that was hit for a milestone causes such a mêlée and such hysteria that special balls have to be used to stop counterfeiting, and police escorts are necessary for those who catch such balls.

Because of Bonds' versatility even some of his early milestones were quite significant. Barry Bonds' milestone home runs have received extensive coverage since his 300th made him the fourth member of the 300–300 club which also included his godfather Willie Mays and father Bobby Bonds. His 400th home run also received national coverage, and his 400–400 feat was a motivating goal and is widely cited as a testament to his greatness. His 500th home run was part of a memorable 2001 Major League Baseball season of milestones in which he hit a record 73 home runs in a single season and surpassed many baseball legends. His 554th home run and 60th of the season sold for US$5000. His 567th and 73rd of the season sold for $500,000, which was far less than the $3 million for which Mark McGwire's 70th had been sold three years earlier. Bonds' 660th home run was more celebrated than his 661st because it put him in the same company as his own godfather on the all-time list. Bonds' 600th and 700th home runs both were widely followed and reported in the media because they placed him such elite company. Bonds' 756th home run sold for $752,467 (including a 20% commission). Below is a list of Barry Bonds' milestone home runs.

Milestone home runs

HR	Date	Age	Team	Pitcher	Opponent	Park	Score	Situation	Runners	Notes
1	June 4, 1986	21 y, 315 d	Pittsburgh	Craig McMurtry	Atlanta	Fulton County Stadium	10–2	T5 2out	---
100	July 12, 1990	25 y, 353 d	Pittsburgh	Andy Benes	San Diego	Three Rivers Stadium	0–0	B1 2out 2–0	12-
200	July 8, 1993	28 y, 349 d	San Francisco	José DeLeón	Philadelphia	Veterans Stadium	11–1	T7 0out 0–0	---
300	April 27, 1996	31 y, 278 d	San Francisco	John Burkett	Florida	Candlestick Park	2–0	B3 0out 0–0	−2-	Becomes the fourth member of the 300–300 club.
400	August 23, 1998	34 y, 30 d	San Francisco	Kirt Ojala	Florida	Pro Player Stadium	3–0	T3 1out 1–1	---	Becomes the first member of the 400–400 club.
500	April 17, 2001	36 y, 267 d	San Francisco	Terry Adams	L.A. Dodgers	Pacific Bell Park	1–2	B8 0out 2–0	--3	Becomes the seventeenth member of the 500 home run club.
554	September 6, 2001	37 y, 44 d	San Francisco	Albie Lopez	Arizona	Pacific Bell Park	4–2	B2 2out 2–2	---	Ties Babe Ruth as the fifth member of the 60 home run club.
564	October 4, 2001	37 y, 72 d	San Francisco	Wilfredo Rodriguez	Houston	Minute Maid Park	9–2	T9 0out 1–1	---	Ties Mark McGwire for first place in single season home runs and as 2nd member of the 70 home run club.
565	October 5, 2001	37 y, 73 d	San Francisco	Chan Ho Park	L.A. Dodgers	Pacific Bell Park	0–5	B1 2out 1–0	---	Surpasses McGwire for first place in single season home runs with 71.
567	October 7, 2001	37 y, 75 d	San Francisco	Dennis Springer	L.A. Dodgers	Pacific Bell Park	0–0	B1 2out 3–2	---	Sets new single season record with 73 home runs. Ownership of ball was disputed in Popov v. Hayashi.
600	August 9, 2002	38 y, 16 d	San Francisco	Kip Wells	Pittsburgh	Pacific Bell Park	2–4	B6 2out 2–1	---	Becomes the fourth member of the 600 home run club.
660	April 12, 2004	39 y, 263 d	San Francisco	Matt Kinney	Milwaukee	SBC Park	2–4	B5 2out 3–1	12-	Ties Willie Mays for third place in career home runs.
661	April 13, 2004	39 y, 264 d	San Francisco	Ben Ford	Milwaukee	SBC Park	3–1	B7 2out 1–2	---	Surpasses Mays for third place in career home runs.
700	September 17, 2004	40 y, 55 d	San Francisco	Jake Peavy	San Diego	SBC Park	3–0	B3 0out 0–1	---	Becomes the third member of the 700 home run club.
714	May 20, 2006	41 y, 300 d	San Francisco	Brad Halsey	Oakland	McAfee Coliseum	0–1	T2 0out 1–1	---	Ties Ruth for second place in career home runs.
715	May 28, 2006	41 y, 308 d	San Francisco	Byung-hyun Kim	Colorado	AT&T Park	0–6	B4 0out 3–2	1--	Surpasses Ruth for second place in career home runs. Also becomes all-time home run leader among left-handed batters.
733	September 22, 2006	42 y, 60 d	San Francisco	Chris Spurling	Milwaukee	Miller Park	8–10	T6 1out 2–0	12-	Ties Hank Aaron for first place in NL career home runs.
734	September 23, 2006	42 y, 61 d	San Francisco	Chris Capuano	Milwaukee	Miller Park	1–6	T3 1out 1–0	---	Surpasses Aaron for first place in NL career home runs.
755	August 4, 2007	43 y, 11 d	San Francisco	Clay Hensley	San Diego	Petco Park	0–1	T2 0out 2–1	---	Ties Aaron for first place in career home runs.
756	August 7, 2007	43 y, 14 d	San Francisco	Mike Bacsik	Washington	AT&T Park	4–4	B5 1out 3–2	---	Surpasses Aaron for first place in career home runs.
762	September 5, 2007	43 y, 43 d	San Francisco	Ubaldo Jiménez	Colorado	Coors Field	0–0	T1 2out 1–2	-2-	Final career home run.

Career home run leaders

Through the 2023 Major League Baseball season, the following are the career home run leaders:

All-time Barry Bonds 762 Hank Aaron 755 Babe Ruth 714 Albert Pujols 703 Alex Rodriguez 696 Willie Mays 660

Active 58. Giancarlo Stanton 401 84. Mike Trout 368 91. Joey Votto 356

See also

• Progression of the single-season MLB home run record