Reptilian humanoids appear in folklore, science fiction, fantasy, and conspiracy theories.

• Adi Shesha  : lit, The first of all the snakes, mount of Hindu God Vishnu; descended to Earth in human form as Lakshmana and Balarama.
• Boreas (Aquilon to the Romans): the Greek god of the cold north wind, described by Pausanias as a winged man, sometimes with serpents instead of feet.
• Cecrops I: the mythical first King of Athens was half man, half snake.
• Chaac: the Maya civilization rain god, depicted in iconography with a human body showing reptilian or amphibian scales, and with a non-human head evincing fangs and a long, pendulous nose.
• Dragon Kings: creatures from Chinese mythology sometimes depicted as reptilian humanoids.
• Some djinn in Islamic mythology are described as alternating between human and serpentine forms.
• Echidna, the wife of Typhon in Greek mythology, was half woman, half snake.
• Fu Xi: serpentine founding figure from Chinese mythology.
• Glycon: a Roman snake god who had the head of a man.
• The Gorgons: Sisters in Greek mythology who had serpents for hair.
• The Lamiai: female phantoms from Greek mythology depicted as half woman, half-serpent.
• Nāga (Devanagari: नाग): half-human half-snake beings from Hindu mythology said to live underground and interact with human beings on the surface.
• Nüwa: serpentine founding figure from Chinese mythology.
• Shenlong: a Chinese dragon thunder god, depicted with a human head and a dragon's body.
• Serpent: an entity from the Genesis creation narrative occasionally depicted with legs, and sometimes identified with Satan, though its representations have been both male and female.
• Sobek: Ancient Egyptian crocodile-headed god.
• Suppon No Yurei: A turtle-headed human ghost from Japanese mythology and folklore.
• Tlaloc: Aztec god depicted as a man with snake fangs.
• Typhon, the "father of all monsters" in Greek mythology, had a hundred snake-heads in Hesiod, or else was a man from the waist up, and a mass of seething vipers from the waist down.
• Xian: immortal beings in Taoism who were sometimes depicted as humanoids with reptile and human features in the Han Dynasty
• Wadjet pre-dynastic snake goddess of Lower Egypt - sometimes depicted as half snake, half woman.
• Zahhak, a figure from Zoroastrian mythology who, in Ferdowsi's epic Shahnameh, grows a serpent on either shoulder.

• Cuca, an humanoid alligator witch from Brazilian folklore.
• Enchanted Moura from Portuguese and Galician folklore appears as a snake with long blonde hair.
• Kappa: Turtle-like humanoids from Japanese mythology and folklore.
• The Lizard Man of Scape Ore Swamp in South Carolina, United States
• The Loveland Frog (or Loveland Lizard), in Loveland, Ohio, United States
• The Thetis Lake monster in Canada
• The White Snake: a figure from Chinese folklore

• Reptilians appear in some claims of alien encounters and in the conspiracy theories of David Icke

• The dinosauroid, a hypothetical reptilian humanoid conjectured by palaeontologist Dale Russell.
• Other speculated sapient dinosaurs

A wide range of fictional works depict reptilian humanoids.

• Dracs from the Enemy Mine series by Barry B. Longyear.
• Evra Von from Darren Shan's "Saga of Darren Shan"
• The Horibs from the Pellucidar books
• The Barabels from Star Wars
• Hork-Bajir from K. A. Applegate's Animorphs
• The Lady of the Green Kirtle from CS Lewis's The Silver Chair who can turn into a giant snake
• An unnamed race from H.P. Lovecraft's The Nameless City - later Cthulhu Mythos tales have named these the Valusians or simply "serpent people".
• The Race from Harry Turtledove's Worldwar series
• The Serpent Men from Robert E. Howard's "The Shadow Kingdom" (also in the Marvel universe)
• Yig, the serpent god from H.P. Lovecraft's Cthulhu Mythos.
• Yilané from the Harry Harrison's novel West of Eden
• The Creeps and the Snake Lady from the Goosebumps franchise.
• The Troglodytes from The Trials of Apollo
• The Green Fangs from The Wingfeather Saga

• Draconians
• Foamasi
• Homo reptilia
  • Silurians
  • Sea Devils
• Ice Warriors

• Cardassians
• Gorn
• Jem'Hadar
• Voth
• Tosk
• Xindi-Reptilians

• Serpentine
• Vermillion

• Bunbo and Iguara from Sailor Moon
• Cobra-La and Cobra Commander from the G.I. Joe series
• Chase Young from Xiaolin Showdown
• The Culebra from From Dusk till Dawn: The Series
• Drakh and Narn from Babylon 5
• Lizard Man, Saurod, the Snake Men, and Whiplash from the Masters of the Universe franchise
• Lizardman Phantom from Kamen Rider Wizard
• The Lizardmen from Sir Arthur Conan Doyle's The Lost World
• Lizardo from The Ambiguously Gay Duo segment of TV Funhouse
• Scarrans from Farscape
• The Sleestaks from Land of the Lost
• Slithe and his fellow Lizards from ThunderCats
• The Snake People from the TV-movie The Archer: Fugitive from the Empire
• Spinner from My Hero Academia
• Tilian from A.T.O.M.
• Unas from Stargate
• Visitors from V
• Zafiro from Disney's Gargoyles is a Gargoyle who has a red-skinned snake-bodied gargate, with two humanoid arms and feathered wings, reminiscent of Kukulcan in Mayan myth and leader of his gargoyle clan
• The Zilards from Mighty Max

• Badoon, another hostile alien race
• Chitauri, alien shapeshifters from the Ultimate Marvel universe.
• Iguana, an enemy of Spider-Man
• Lizard, an enemy of Spider-Man
• The Lizard Men of Subterranea
• The Lizard Men of the Savage Land
• The Lizard Men of Tok from the Microverse
• Sauron, a Pteranodon-like enemy of the X-Men
• Skrulls, an alien race of reptilian shapeshifters
• Slither, a snake-like mutant and ally of Magneto who has been a member of the Resistants and the Serpent Society
• Stegron, a Stegosaurus-like enemy of Spider-Man
• Zn'rx (Snarks), a race of reptilian aliens bipeds encountered by the Power Pack

• Copperhead, some versions are part snake
• Gordanians, a species of alien reptilian slavers
• Killer Croc, an enemy of Batman
• The Lizardmen from the Warlord series.
• The Llarans
• The Psions

• Dinosaurs for Hire, dinosaur-like alien mercenaries
• Henry Phage from the Mr. Hero comics from Tekno Comix
• Kleggs, alien mercenaries in the Judge Dredd universe.
• The Teenage Mutant Ninja Turtles, Slash, Leatherhead, and even the Triceratons.
• Treens from Dan Dare
• Tyranny Rex, a reptilian artist in stories published in 2000AD.
• Zarbon from anime and manga Dragon Ball Z.
• Calliope, a reptilian figure of prophecies, from Homestuck

• Draco from Above Majestic
• Dracs from Enemy Mine
• Lectroids from Buckaroo Banzai
• Snake Men from Masters of the Universe
• Snake People from the TV movie The Archer: Fugitive from the Empire
• Thulsa Doom from Conan the Barbarian
• Trandoshans from Star Wars

• Argonians, a race in The Elder Scrolls series
• Bangaa, a race in the game series of Final Fantasy
• Drell, a race in the Mass Effect series
• Dinaurians from Fossil Fighters and Fossil Fighters: Champions
• Iksar, a race from the EverQuest franchise.
• Lizalfos from the Legend of Zelda series.
• Lizardmen from the Warhammer fantasy tabletop games.
• Naga from the Warcraft series.
• Reptites from Chrono Trigger
• Saurians from Risen
• Susie from Deltarune

• Kobolds
• Lizardfolk
• Saurial
• Troglodytes
• Yuan-ti

• Bowser and the Koopas from Mario
• Espio the Chameleon and Vector the Crocodile from Sonic the Hedgehog
• Lizardman, a character from the Soul series of fighting games
• Locust Horde, the primary antagonists in the game franchise Gears of War
• King K. Rool and most Kremlings from Donkey Kong
• Reptile, Chameleon, and Khameleon from the video game series Mortal Kombat
• Riptor, a character from the fighting game Killer Instinct

• List of avian humanoids
• List of piscine and amphibian humanoids
• List of dragons in literature
• Insectoids in science fiction and fantasy