Louisburg Historic District is a national historic district located at Louisburg, Franklin County, North Carolina. The district encompasses 206 contributing buildings, 1 contributing site, 6 contributing structures, and 1 contributing object in residential sections of Louisburg included in the original 1779 town plan. It also includes a section of Louisburg College located on the old Town Commons. Dwellings date between about 1800 and the 1920s and include notable examples of popular architectural styles including Federal / Georgian, Italianate / Greek Revival, Queen Anne, Colonial Revival, Late Victorian, and Bungalow / American Craftsman. Located in the district and separately listed are the Fuller House, Williamson House, and Main Building, Louisburg College. Other notable buildings include the Shine-King House (c. 1800), Milner-Perry-Boddie-Dennis House (c. 1779), Dr. J.B. Clifton House (c. 1865), The Edgerton-Pruitt House (c. 1905), The Furgurson-Hicks House (c. 1908), Nicholson-Bickett-Taylor House (c. 1897), The Hughes-Watson-Wheless House (c. 1900), Bailey-Yarborough House (c. 1895), The Barrow House (c. 1888–1890), The Neal-Webb House (c. 1904), The Milner-Williams-Person Place (c. 1789–1830), Former Rectory-St. Paul's Episcopal Church, Hicks-Perry-Bland-Holmes House (c. 1914), Malcomb McKinne House (c. 1922) First Baptist Church (1927), Louisburg United Methodist Church (1900), and Louisburg Baptist Church (1901-1904).

It was listed on the National Register of Historic Places in 1987.