Louisville (/ˈluːɪsvɪl/; ; formerly Lewisville and still pronounced as such) is a town in Barbour County, Alabama, United States. The population was 395 as of the 2020 census.

Louisville is 10 miles (16 km) southwest of Clayton, the county seat, and 6 miles (10 km) northeast of Clio.

According to the U.S. Census Bureau, the town has a total area of 2.8 square miles (7.1 km), all land.

Historical population

Census	Pop.	Note	%±
1880	211		—
1890	288		36.5%
1900	416		44.4%
1910	483		16.1%
1920	504		4.3%
1930	587		16.5%
1940	662		12.8%
1950	622		−6.0%
1960	890		43.1%
1970	785		−11.8%
1980	791		0.8%
1990	728		−8.0%
2000	612		−15.9%
2010	519		−15.2%
2020	395		−23.9%
U.S. Decennial Census 2013 Estimate

Louisville racial composition

Race	Num.	Perc.
White (non-Hispanic)	193	48.86%
Black or African American (non-Hispanic)	171	43.29%
Asian	1	0.25%
Other/Mixed	9	2.28%
Hispanic or Latino	21	5.32%

As of the 2020 United States census, there were 395 people, 238 households, and 141 families residing in the town.

At the 2000 census there were 612 people, 242 households, and 168 families in the town. The population density was 222.8 inhabitants per square mile (86.0/km). There were 271 housing units at an average density of 98.6 per square mile (38.1/km). The racial makeup of the town was 52.94% White, 40.69% Black or African American, 0.65% Native American, 5.23% from other races, and 0.49% from two or more races. 6.37% of the population were Hispanic or Latino of any race. Of the 242 households, 26.9% had children under the age of 18 living with them, 52.5% were married couples living together, 14.0% had a female householder with no husband present, and 30.2% were non-families. 26.9% of households were one person and 16.5% were one person aged 65 or older. The average household size was 2.53 and the average family size was 3.05.

The age distribution was 23.7% under the age of 18, 10.6% from 18 to 24, 23.2% from 25 to 44, 22.1% from 45 to 64, and 20.4% 65 or older. The median age was 39 years. For every 100 females, there were 87.7 males. For every 100 females age 18 and over, there were 85.3 males.

The median household income was $20,859 and the median family income was $27,014. Males had a median income of $27,500 versus $24,583 for females. The per capita income for the town was $13,151. About 22.4% of families and 28.0% of the population were below the poverty line, including 22.0% of those under age 18 and 34.8% of those age 65 or over.

• George M. Grant, former U.S. Representative
• Jeremiah Norman Williams, U.S. Representative from Alabama's 2nd congressional district from 1875 to 1877

• 
  The Louisville City Hall, Police Department, and Public Library
• 
  Louisville Fire Department
• 
  The Old Louisville School (established 1916)
• 
  This historic marker denotes the former location of the Pike/Barbour County courthouse in Louisville.