Lucy and J. Vassie Wilson House is a historic home located at High Point, Guilford County, North Carolina. It was built in 1926, and is a two-story, three-bay, Colonial Revival-style brick dwelling. It has a tile hipped roof, porte-cochère, and features a semicircular columned porch supported by four columns with stylized Corinthian order capitals. Also on the property is a contributing three-car brick garage.

It was listed on the National Register of Historic Places in 2005. It is located in the Uptown Suburbs Historic District.