Luthersburg is an unincorporated community in Clearfield County, Pennsylvania, United States. The community is located at the intersection of U.S. routes 219 and 322, and Pennsylvania Route 410, 5.1 miles (8.2 km) south-southeast of DuBois. Luthersburg has a post office, with ZIP code 15848.

The community was named for W. H. Luther, an early settler.