Lyon-Vaise station (French: Gare de Lyon-Vaise) is a railway station in Lyon, located in the district of Vaise, in the 9th arrondissement. The station is on the historical Paris–Lyon–Marseille (PLM) main line; it is also served by Lyon Metro Line D of which it is the northwestern terminus.

From 10 July 1854 until the opening of the Saint-Irenée tunnel between Vaise and Perrache railway station on 10 October 1856, the station was the Lyon terminus of trains from Chalon-sur-Saône and Paris.

Lyon-Vaise was destroyed during the bombings of 26 May 1944. It was provisionally rebuilt in wood, then a new station was opened in 1956. In 1997, a new multimodal space was built to facilitate connections between the train, metro and bus.

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  Earlier station building
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  Lyon-Vaise in 2008
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  Inside the building from the street, SNCF railway station is located upstairs while métro and buses are accessible downstairs
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  An access to the platforms
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  An access to the platforms
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  Underground passage to the platforms
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  Tracks and platforms (May 2019)
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  Platform of track A (October 2019)
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  A Z 24500 on a TER to Mâcon-Ville (May 2019)
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  The métro station of line D
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  The TCL bus station served by 21 bus and trolleybus lines

The station is served by regional trains towards Mâcon, Nevers, Bourg-en-Bresse, Vienne and Roanne.

• Transport in Rhône-Alpes
• Lyon Metro

45°46′48″N 4°48′14″E / 45.780135°N 4.803781°E / 45.780135; 4.803781