Lyozna (Belarusian: Лёзна, romanized: Liozna; Russian: Лиозно, romanized: Liozno; Polish: Łoźna; German: Ljesno; Yiddish: ליאזנע, romanized: Lyozne) is an urban-type settlement in Vitebsk Region, Belarus. It serves as the administrative center of Lyozna District. It is located 45 kilometres (28 mi) east-southeast of Vitebsk, close to the border with Russia by the Vitebsk–Smolensk railroad branch and highway, on the Moshna River. As of 2024, it has a population of 6,605.

The first known record of the Lyozna shtetl (small town with a high Jewish population) is dated 1654.

In 1939, 711 Jews lived in the settlement, making up 17.3 percent of the population.

During the German invasion of the Soviet Union, the settlement was captured on 16 July 1941 by V Army Corps of the 9th Army; it was part of Army Group Centre Rear Area. The ghetto in Lyozna was liquidated at the end of February 1942. Lyozna remained under German military occupation until 8 October 1943.

• Marc Chagall, Belarusian-French painter
• Schneur Zalman, the first Rebbe of the Chabad-Lubavitch Hasidic dynasty
• Dovber Schneuri, the second Rebbe of the Chabad-Lubavitch Hasidic dynasty
• Menachem Mendel Schneersohn, the third Rebbe of the Chabad-Lubavitch Hasidic dynasty

• Megargee, Geoffrey P.; Dean, Martin (4 May 2012). The United States Holocaust Memorial Museum Encyclopedia of Camps and Ghettos, 1933 –1945: Volume II: Ghettos in German-Occupied Eastern Europe. Indiana University Press. ISBN 978-0-253-00202-0.

• Lyozna home page
• Lyozna book memory
• Lyozna newspaper "Styag Peramogi"
• Lyozna satellite image
• The murder of the Jews of Lyozna during World War II, at Yad Vashem website
• Lyëzna, Belarus at JewishGen