Madikwe Game Reserve is a protected area in South Africa and was named after the Madikwe or Marico River, on whose basin it is located. It comprises 750 km (290 sq mi) of bushland north of the small town of Groot-Marico up to the border with Botswana. It was opened in 1994.

Madikwe Game Reserve is currently the fifth largest game reserve in South Africa encompassing 750 km (290 sq mi), including the now incorporated privately owned land. The area used to be farmland, but due to the poor soil type, farming was not that successful. After extensive research, the South African government found that this land would best be utilised as a game reserve, to economically uplift this otherwise rather poor area.

The process of reintroducing wildlife to the area began in 1992 under the codename Operation Phoenix which relocated entire breeding herds of the African bush elephant, African buffalo as well as south-central black rhinoceros and southern white rhinoceros along with various species of antelopes. Following Operation Phoenix, Madikwe also successfully reintroduced predatory species such as lion, cheetah, spotted hyena and African wild dog so that more than 60 mammal species occur in the game reserve.

The terrain is mainly open grasslands and bushveld plains, interspersed with rocky outcrops and single mountains.

Madikwe forms part of a semi-arid region on the edge of the Kalahari desert. In this region the climate can be broken into the rainy season (October – April) and the dry season (May – September). Summers overlap with the rainy season. Temperatures are high (32 °C / 90 °F) with cooling thunderstorms common in the late afternoon, evenings are mild (18 °C / 64 °F). Winters here are dry, with mild days (21 °C / 70 °F) and chilly nights (3 °C / 37 °F). Game viewing is good at all times of the year though most animals tend to congregate around available water sources during the winter.

• Madikwe Game Reserve official website