Mainz experiences an oceanic climate (Köppen climate classification: Cfb).

The Roman stronghold or castrum Mogontiacum, the precursor to Mainz, was founded by the Roman general Drusus perhaps as early as 13/12 BC. As related by Suetonius the existence of Mogontiacum is well established by four years later (the account of the death and funeral of Nero Claudius Drusus). Although the city is situated opposite the mouth of the Main, the name of Mainz is not from Main, the similarity being perhaps reinforced by folk-etymological reanalysis. Main is from Latin Moenis (also Moenus or Menus), the name the Romans used for the river. Linguistic analysis of the many forms that the name "Mainz" has taken on make it clear that it is a simplification of Mogontiacum. The name appears to be Celtic, however, it had also become Roman and was selected by them with a special significance. The Roman soldiers defending Gallia had adopted the Gallic god Mogons (Mogounus, Moguns, Mogonino), for the meaning of which etymology offers two basic options: "the great one", similar to Latin magnus, which was used in aggrandizing names such as Alexander magnus, "Alexander the Great" and Pompeius magnus, "Pompey the great", or the god of "might" personified as it appears in young servitors of any type whether of noble or ignoble birth.

Mogontiacum was an important military town throughout Roman times, probably due to its strategic position at the confluence of the Main and the Rhine. The town of Mogontiacum grew up between the fort and the river. The castrum was the base of Legio XIV Gemina and XVI Gallica (AD 9–43), XXII Primigenia, IV Macedonica (43–70), I Adiutrix (70–88), XXI Rapax (70–89), and XIV Gemina (70–92), among others. Mainz was also a base of a Roman river fleet, the Classis Germanica. Remains of Roman troop ships (navis lusoria) and a patrol boat from the late 4th century were discovered in 1982/86 and may now be viewed in the Museum für Antike Schifffahrt. A temple dedicated to Isis Panthea and Magna Mater was discovered in 2000 and is open to the public. The city was the provincial capital of Germania Superior, and had an important funeral monument dedicated to Drusus, to which people made pilgrimages for an annual festival from as far away as Lyon. Among the famous buildings were the largest theatre north of the Alps and a bridge across the Rhine. The city was also the site of the assassination of emperor Severus Alexander in 235.

Alemanni forces under Rando sacked the city in 368. From the last day of 405 or 406, the Siling and Asding Vandals, the Suebi, the Alans, and other Germanic tribes crossed the Rhine, possibly at Mainz. Christian chronicles relate that the bishop, Aureus, was put to death by the Alemannian Crocus.

Throughout the changes of time, the Roman castrum never seems to have been permanently abandoned as a military installation, which is a testimony to Roman military judgement. Different structures were built there at different times. The current citadel originated in 1660, but it replaced previous forts. It was used in World War II. One of the sights at the citadel is still the cenotaph raised by legionaries to commemorate their general, Drusus.

In the 4th century, Alemans repeatedly invaded the neighborhood of Mogontiacum. In 357, the city was liberated by the Emperor Julian. The last emperor to station troops serving the western empire at Mainz was Valentinian III (reigned 425–455), who relied heavily on his Magister militum per Gallias, Flavius Aëtius. In 451, Attila's Huns sacked the city.

The Franks from the middle and upper Rhine area took Mainz shortly before 460. After the fall of the Western Roman Empire in 476, the Franks under the rule of Clovis I gained control over western Europe by the year 496. Clovis, son of Childeric, became king of the Salians in 481, ruling from Tournai. He converted from paganism to Catholic Christianity. Theudebert I (c. 500–547 or 548) had installed Sidonius [de] as bishop of Mainz. Dagobert I (605/603–639) reinforced the walls of Mainz.

Charlemagne (768–814), through a succession of wars against other tribes, built a vast Frankish empire in Europe. Mainz from its central location became important to the empire and to Christianity. Meanwhile, language change was gradually working to divide the Franks. After the death of Charlemagne, distinctions between France and Germany began to be made. The Rhine roughly formed the border of their territories, whereby the three important episcopal cities of Mainz, Worms and Speyer with their counties to the left of the Rhine were assigned to East Francia.

Free City of Mainz Freie Stadt Mainz
1244–1462
Status	Imperial city
Capital	Mainz
Historical era	Middle Ages
• City established	c. 13 BC
• City charter granted    by Abp Siegfried III	1244
• Rival archbishops	1461
• Charter revoked by    Abp Adolph II	1462
• German Mediatisation	1803
Preceded by Succeeded by Archbishopric of Mainz Archbishopric of Mainz

In the early Middle Ages, Mainz played a significant role in the Christianisation of the German and Slavic peoples. The first archbishop in Mainz, Boniface, was killed in 754 while attempting to convert the Frisians to Christianity and is buried in Fulda. The archbishopric of Mainz was established in 781 when Boniface's successor Lullus was granted the pallium by Pope Adrian I. Throughout history, the Archbishops of Mainz held high positions, including serving as archchancellors of the Holy Roman Empire. Notably, the Roman Catholic Diocese of Mainz is unique as it is the only diocese in the world with an episcopal see called a Holy See (sancta sedes).

Ibrahim ibn Yaqub, a 10th-century Hispano-Arabic, Sephardi Jewish traveler, writes the following about the city:

"Mainz [Maghānja] is a very large city, partly inhabited and partly cultivated fields. It is in the land of the Franks, on a river called the Rhine [Rīn]. Wheat, barley, rye, grapevines and fruit are plentiful."

In 1244, Archbishop Siegfried III granted Mainz a city charter, allowing the citizens to establish and elect a city council. In 1461, a feud between two archbishops, Diether von Isenburg and Adolf II von Nassau, caused unrest in the city. Following Archbishop Adolf's raid on Mainz in 1462, those who opposed him, including Johannes Gutenberg, were either expelled or imprisoned. Ultimately, after the death of Archbishop Adolf II, Diether von Isenburg was reinstated as the Archbishop of Mainz, duly elected by the chapter and appointed by the Pope.

• 
  Mainz Cathedral, western main tower
• 
  Monument to St. Boniface before Mainz Cathedral
• 
  St. Martin's Cathedral in Mainz, by Wenzel Hollar; pen-and-ink drawing 1632

The Jewish community of Mainz dates to the 10th century CE. It is noted for its religious education. Rabbi Gershom ben Judah (960–1040) taught there, among others. He concentrated on the study of the Talmud, creating a German Jewish tradition. Mainz is also the legendary home of the martyred Rabbi Amnon of Mainz, composer of the Unetanneh Tokef prayer. From the late 12th century rabbis met in synods.

The city of Mainz responded to the Jewish population in a variety of ways, behaving in a capricious manner towards them. Sometimes they were allowed freedom and were protected; at other times, they were persecuted. The Jews were expelled in 1438, 1462 (after which they were invited to return), and in 1470. Jews were attacked in the Rhineland massacres of 1096 and by mobs in 1283. Outbreaks of the Black Death were usually blamed on the Jews, at which times they were massacred, such as the murder of 6000 Jews in 1349.

Outside of the medieval city centre, there is a Jewish cemetery, with over 1500 headstones dating from the 11th through the 19th centuries. The earliest known gravestone is date to 1062 or 1063, and these early gravestones resemble those found in Italy in the 8th–9th centuries.

Nowadays the Jewish community is growing rapidly, and a new synagogue by the architect Manuel Herz was constructed in 2010 on the site of the one destroyed by the Nazis on Kristallnacht in 1938. As of 2021, the Jewish community Mainz has 985 members.

During the French Revolution, the French Revolutionary army occupied Mainz in 1792; the Archbishop-elector of Mainz, Friedrich Karl Josef von Erthal, had already fled to Aschaffenburg by the time the French marched in. On 18 March 1793, the Jacobins of Mainz, with other German democrats from about 130 towns in the Rhenish Palatinate, proclaimed the 'Republic of Mainz'. Led by Georg Forster, representatives of the Mainz Republic in Paris requested political affiliation of the Mainz Republic with France, but too late: Prussia was not entirely happy with the idea of a democratic free state on German soil (although the French dominated Mainz was neither free nor democratic). Prussian troops had already occupied the area and besieged Mainz by the end of March 1793. After a siege of 18 weeks, the French troops in Mainz surrendered on 23 July 1793; Prussians occupied the city and ended the Republic of Mainz. It came to the Battle of Mainz in 1795 between Austria and France. Members of the Mainz Jacobin Club were mistreated or imprisoned and punished for treason.

In 1797, the French returned. The army of Napoleon Bonaparte occupied the German territory to the west of the Rhine, and the Treaty of Campo Formio awarded France this entire area, initially as the Cisrhenian Republic. On 17 February 1800, the French Département du Mont-Tonnerre was founded here, with Mainz as its capital, the Rhine being the new eastern frontier of la Grande Nation. Austria and Prussia could not but approve this new border with France in 1801. However, after several defeats in Europe during the War of the Sixth Coalition, the weakened Napoleon and his troops had to leave Mainz in May 1814.

In 1816, the part of the former French Département which is known today as Rhenish Hesse (German: Rheinhessen) was awarded to the Hesse-Darmstadt, Mainz being the capital of the new Hessian province of Rhenish Hesse. From 1816 to 1866, a part of the German Confederation, Mainz was the most important fortress in the defence against France, and had a strong garrison of Austrian, Prussian and Bavarian troops.

On the afternoon of 18 November 1857, a huge explosion rocked Mainz when the city's powder magazine, the Pulverturm, exploded. Approximately 150 people were killed and at least 500 injured; 57 buildings were destroyed and a similar number severely damaged in what was to be known as the Powder Tower Explosion or Powder Explosion.

During the Austro-Prussian War in 1866, Mainz was declared a neutral zone. After the founding of the German Empire in 1871, Mainz no longer was as important a stronghold, because in the Franco-Prussian War France had lost the territory of Alsace-Lorraine to Germany (which France had occupied bit by bit from 1630 to 1795), and this defined the new border between the two countries.

For centuries the inhabitants of the fortress of Mainz had suffered from a severe shortage of space which led to disease and other inconveniences. In 1872 Mayor Carl Wallau and the council of Mainz persuaded the military government to sign a contract to expand the city. Beginning in 1874, the city of Mainz assimilated the Gartenfeld, an idyllic area of meadows and fields along the banks of the Rhine to the north of the rampart. The city expansion more than doubled the urban area which allowed Mainz to participate in the industrial revolution which had previously avoided the city for decades.

Eduard Kreyßig [de] was the man who made this happen. Having been the master-builder of the city of Mainz since 1865, Kreyßig had the vision for the new part of town, the Neustadt. He also planned the first sewer system for the old part of town since Roman times and persuaded the city government to relocate the railway line from the Rhine side to the west end of the town. The main station was built from 1882 to 1884 according to the plans of Philipp Johann Berdellé [de].

Kreyßig constructed a number of state-of-the-art public buildings, including the Mainz town hall – which was the largest of its kind in Germany at that time – as well a synagogue, the Rhine harbour and a number of public baths and school buildings. Kreyßig's last work was Christ Church (Christuskirche), the largest Protestant church in the city and the first building constructed solely for the use of a Protestant congregation. In 1905 the demolition of the entire circumvallation and the Rheingauwall was taken in hand, according to the imperial order of Wilhelm II.

During the German Revolution of 1918 the Mainz Workers' and Soldiers' Council was formed which ran the city from 9 November until the arrival of French troops under the terms of the occupation of the Rhineland agreed in the Armistice. The French occupation was confirmed by the Treaty of Versailles which went into effect 28 June 1919. The Rhineland (in which Mainz is located) was to be a demilitarized zone until 1935 and the French garrison, representing the Triple Entente, was to stay until reparations were paid.

In 1923 Mainz participated in the Rhineland separatist movement that proclaimed a Rhenish Republic. It collapsed in 1924. The French withdrew on 30 June 1930. Adolf Hitler became chancellor of Germany in January 1933 and his political opponents, especially those of the Social Democratic Party, were either incarcerated or murdered. Some were able to move away from Mainz in time. One was the political organizer for the SPD, Friedrich Kellner, who went to Laubach, where, as the chief justice inspector of the district court, he continued his opposition against the Nazis by recording their misdeeds in a 900-page diary.

In March 1933, a detachment from the National Socialist Party in Worms brought the party to Mainz. They hoisted the swastika on all public buildings and began to denounce the Jewish population in the newspapers. In 1936, the Nazis remilitarized the Rhineland with great fanfare, the first move of Nazi Germany's meteoric expansion. The former Triple Entente took no action.

During World War II the citadel at Mainz hosted the Oflag XII-B prisoner of war camp. The city was also the location of four subcamps of the Hinzert concentration camp, mostly for Luxembourgish, Polish, Dutch and Soviet prisoners, but also Belgian, French and Italian.

During World War II, several air raids destroyed about 80 per cent of the city's centre, including most of the historic buildings. Mainz was captured on 22 March 1945 against uneven German resistance (staunch in some sectors and weak in other parts of the city) by the 90th Infantry Division under William A. McNulty, a formation of the XII Corps under Third Army commanded by General George S. Patton Jr.

From 1945 to 1949, the city was part of the French zone of occupation. When the state of Rhineland-Palatinate was founded on 30 August 1946 by the commander of the French army on the French occupation zone Marie Pierre Kœnig, Mainz became the capital of the new state. In 1962, the diarist, Friedrich Kellner, returned to spend his last years in Mainz. His life in Mainz, and the impact of his writings, is the subject of the Canadian documentary My Opposition: The Diaries of Friedrich Kellner.

Following the withdrawal of French forces from Mainz, the United States Army Europe occupied the military bases in Mainz. Today United States Army Europe and Africa only occupies McCulley Barracks in Wackernheim and the Mainz Sand Dunes for the training areas. Mainz is home to the headquarters of the Bundeswehr's Landeskommando Rhineland-Palatinate [de] and other units.

The destruction caused by the Bombing of Mainz in World War II led to the most intense phase of building in the history of the town. During the last war in Germany, more than 30 air raids destroyed about 80 per cent of the city's centre, including most of the historic buildings. The attack on the afternoon of 27 February 1945 remains the most destructive of all 33 bombings that Mainz has suffered in World War II in the collective memory of most of the population living then. The air raid caused most of the dead and made an already hard-hit city largely levelled. Nevertheless, the post-war reconstruction took place very slowly. While cities such as Frankfurt had been rebuilt fast by a central authority, only individual efforts were initially successful in rebuilding Mainz. The reason for this was that the French wanted Mainz to expand and become a model city. Mainz lay within the French-controlled sector of Germany and it was a French architect and town-planner, Marcel Lods, who produced a Le Corbusier-style plan of an ideal architecture. But the first interest of the inhabitants was the restoration of housing areas. Even after the failure of the model city plans it was the initiative of the French (founding of the Johannes Gutenberg University of Mainz, elevation of Mainz to the state capital of Rhineland-Palatinate, the early resumption of the Mainz carnival) driving the city in a positive development after the war. The City Plan of 1958 by Ernst May allowed a regulated reconstruction for the first time. In 1950, the seat of the government of Rhineland-Palatinate had been transferred to the new Mainz and in 1963 the seat of the new ZDF, notable architects were Adolf Bayer, Richard Jörg and Egon Hartmann. At the time of the two-thousand-years-anniversary in 1962 the city was largely reconstructed. During the 1950s and 1960s, the Oberstadt had been extended, Münchfeld and Lerchenberg added as suburbs, the Altstadttangente (intersection of the old town), new neighbourhoods as Westring and Südring contributed to the extension. By 1970 there remained only a few ruins. The new town hall of Mainz had been designed by Arne Jacobsen and finished by Dissing+Weitling. The town used Jacobsens activity for the Danish Novo company erecting a new office and warehouse building to contact him. The urban renewal of the old town changed the inner city. In the framework of the preparation of the cathedrals millennium, pedestrian zones were developed around the cathedral, in northern direction to the Neubrunnenplatz and in a southern direction across the Leichhof to the Augustinerstraße and Kirschgarten. The 1980s brought the renewal of the façades on the Markt and a new inner-city neighbourhood on the Kästrich. During the 1990s the Kisselberg and the "Fort Malakoff Center" at the site of the old police barracks were built.

• Romano-Germanic Central Museum (Römisch-Germanisches Zentralmuseum). It is home to Roman, Medieval, and earlier artifacts.
• Museum of Ancient Seafaring (Museum für Antike Schifffahrt). It houses the remains of five Roman boats from the late 4th century, discovered in the 1980s.
• Roman remains, including Jupiter's column, Drusus' mausoleum, the ruins of the theatre and the aqueduct.
• Mainz Cathedral of St. Martin (Mainzer Dom), over 1,000 years old.
• St. John's Church, 7th-century church building
• Staatstheater Mainz
• The Iron Tower (Eisenturm, tower at the former iron market), a 13th-century gate-tower.
• The Wood Tower (Holzturm, tower at the former wood market), a 15th-century gate tower.
• The Gutenberg Museum – exhibits an original Gutenberg Bible amongst many other printed books from the 15th century and later.
• The Mainz Old Town – what's left of it, the half south of the cathedral survived World War II.
• The old arsenal, the central arsenal of the fortress Mainz during the 17th and 18th century
• The Electoral Palace (Kurfürstliches Schloss), residence of the prince-elector.
• The Marktbrunnen, one of the largest Renaissance fountains in Germany.
• Domus Universitatis (1615), for centuries the tallest edifice in Mainz.
• Christ Church (Christuskirche), built 1898–1903, bombed in 1945 and rebuilt in 1948–1954.
• The Church of St. Stephan, with post-war windows by Marc Chagall.
• Citadel.
• The ruins of the church St. Christoph, a World War II memorial
• Schönborner Hof (1668).
• Rococo churches of St. Augustin (the Augustinerkirche, Mainz) and St. Peter (the Peterskirche, Mainz).
• Churches of St. Ignatius (1763) and St. Quintin.
• Erthaler Hof (1743)
• The Baroque Bassenheimer Hof (1750)
• The Botanischer Garten der Johannes Gutenberg-Universität Mainz, a botanical garden maintained by the university
• Landesmuseum Mainz, state museum with archaeology and art.
• Zweites Deutsches Fernsehen (ZDF) – one of the largest public German TV-Broadcaster.
• New synagogue in Mainz
• Old Jewish Cemetery Mainz (Judensand) – ShUM city of Mainz, UNESCO World Heritage Site
• Kunsthalle Mainz – museum for contemporary art
• Humbrechthof, later called Schöfferhof, the building in which Johannes Gutenberg developed his technique of printing

The city of Mainz is divided into 15 local districts according to the main statute of the city of Mainz. Each local district has a district administration of 13 members and a directly elected mayor, who is the chairman of the district administration. This local council decides on important issues affecting the local area, however, the final decision on new policies is made by Mainz's municipal council.

In accordance with section 29 paragraph 2 Local Government Act of Rhineland-Palatinate, which refers to municipalities of more than 150,000 inhabitants, the city council has 60 members.

Districts of the town are:

Until 1945, the districts of Bischofsheim (now an independent town), Ginsheim-Gustavsburg (which together are an independent town) belonged to Mainz. The former districts Amöneburg, Kastel, and Kostheim – (in short, AKK) are now administered by the city of Wiesbaden (on the north bank of the river). The AKK was separated from Mainz when the Rhine was designated the boundary between the French occupation zone (the later state of Rhineland-Palatinate) and the U.S. occupation zone (Hesse) in 1945.

The coat of arms of Mainz is derived from the coat of arms of the Archbishops of Mainz and features two six-spoked silver wheels connected by a silver cross on a red background.

Mainz has a population of about 220,000 and is the largest city in Rhineland-Palatinate. Mainz passed 100,000 in 1908. In 1945, After WWII, right side of the Rhine river, which were a part of Mainz, became a part of Wiesbaden and other part of Hesse due to its occupation zone where Mainz and Rhineland-Palatinate were French occupation zone and Wiesbaden and Hesse were American occupation zone where both cities became its state capital in 1946. Mainz lost 21.1% of population at this time. Mainz and Wiesbaden has rivalries who the better city on the Rhine river are even today. Mainz became an attractive city, especially for young people due to its radio and television broadcasters, Universities and good workplaces. Mainz's population grow normally and Mainz passed 200,000 in 2011.

The following list shows the largest foreign populations in Mainz as of 2022:

Rank	Nationality	Population (2022)
1	Turkey	5,424
2	Italy	3,875
3	Poland	3,300
4	Serbia	2,739
5	Ukraine	2,587
6	Bulgaria	2,126
7	Portugal	1,920
8	Russia	1,790
9	Syria	1,612
10	Morocco	1,325
11	Spain	1,106
12	France	942

The mayor of Mainz was Michael Ebling of the Social Democratic Party (SPD) until he was promoted State Minister of the Interior in the government of Rhineland-Palatinate in October 2022. The new mayoral election was held on 12 February 2023, with a runoff after Mainz carnival. The final election took place 5 March 2023. The new elected mayor is Nino Haase, independent.

Election 2019 of the council:

The Mainz city council governs the city alongside the Mayor. The most recent city council election was held on 26 May 2019, and the results were as follows:

Party		Votes	%	+/-	Seats	+/-
	Alliance 90/The Greens (Grüne)	1,582,459	27.7	7.5	17	5
	Christian Democratic Union (CDU)	1,339,561	23.5	6.9	14	4
	Social Democratic Party (SPD)	1,151,572	20.2	7.2	12	5
	Free Democratic Party (FDP)	340,501	6.0	0.9	4	1
	The Left (Die Linke)	335,459	5.9	1.3	4	1
	Alternative for Germany (AfD)	302,604	5.3	2.3	3	1
	Ecological Democratic Party (ÖDP)	238,727	4.2	0.2	2	±0
	Die PARTEI	127,581	2.2	New	1	New
	Free Voters (FW)	108,701	1.9	0.9	1	±0
	Pirate Party (Piraten)	78,595	1.4	0.4	1	±0
	Volt Germany (Volt)	67,376	1.2	New	1	New
	Alliance for Innovation and Justice (BIG)	31,419	0.6	0.1	0	±0
Total votes		5,704,555	100.0
Total ballots		100,522	100.0		60	±0
Electorate/voter turnout		162,321	61.9	11.0
Source: City of Mainz

Mainz is home to a Carnival, the Mainzer Fassenacht or Fastnacht, which has developed since the early 19th century. Carnival in Mainz has its roots in the criticism of social and political injustices under the shelter of cap and bells. Today, the uniforms of many traditional Carnival clubs still imitate and caricature the uniforms of the French and Prussian troops of the past. The height of the carnival season is on Rosenmontag ("rose Monday"), when there is a large parade in Mainz, with more than 500,000 people celebrating in the streets.

The first-ever Katholikentag, a festival-like gathering of German Catholics, was held in Mainz in 1848.

Johannes Gutenberg, credited with the invention of a modern printing press with movable type, was born here and died here. Since 1968 the Mainzer Johannisnacht commemorates the person Johannes Gutenberg in his native city. The Mainz University, which was refounded in 1946, is named after Gutenberg; the earlier University of Mainz that dated back to 1477 had been closed down by Napoleon's troops in 1798.

Mainz was one of three important centres of Jewish theology and learning in Central Europe during the Middle Ages. Known collectively as Shum, the cities of Speyer, Worms and Mainz played a key role in the preservation and propagation of Talmudic scholarship.

The city is the seat of Zweites Deutsches Fernsehen (literally, "Second German Television", ZDF), one of two federal nationwide TV broadcasters. There are also a couple of radio stations based in Mainz. The Mainzer Stadtschreiber (City clerk in Mainz) is an annual German literature award.

Other cultural aspects of the city include:

• As city in the Greater Region, Mainz participated in the program of the year of European Capital of Culture 2007.
• The Walk of Fame of Cabaret may be found nearby the Schillerplatz.
• The music publisher Schott Music is located in Mainz.
• One of the oldest brass instrument manufacturers in the world, Gebr. Alexander is located in Mainz.
• Fans of Gospel music enjoy the yearly performances of Colours of Gospel.
• Every one or two years a festival for improvised music between jazz, avant-garde and rock with a line-up of international renowned musicians takes place, the Akut-Festival.

• University of Mainz
• University of Applied Sciences Mainz
• Catholic University of Applied Sciences Mainz

The local football club 1. FSV Mainz 05 has a long history in the German football leagues. Since 2004 it has competed in the Bundesliga (First German soccer league) except a break in second level in 2007–08 season. Mainz is closely associated with renowned coach Jürgen Klopp, who spent the vast majority of his playing career at the club and was also the manager for seven years, leading the club to Bundesliga football for the first time. After leaving Mainz Klopp went on to win two Bundesliga titles and reaching a Champions League final with Borussia Dortmund. In the summer of 2011, the club opened its new stadium called Coface Arena, which was later renamed Opel Arena. Further relevant football clubs are TSV Schott Mainz, SV Gonsenheim, Fontana Finthen, FC Fortuna Mombach and FVgg Mombach 03.

The local wrestling club ASV Mainz 1888 is currently in the top division of team wrestling in Germany, the Bundesliga. In 1973, 1977, 2012 and 2023 the ASV Mainz 1888 won the German championship.

In 2007 the Mainz Athletics won the German Men's Championship in baseball.

As a result of the 2008 invasion of Georgia by Russian troops, Mainz acted as a neutral venue for the Georgian Vs Republic of Ireland football game.

The biggest basketball club in the city is the ASC Theresianum Mainz. Its men's team is playing in the Regionalliga and its women's team is playing in the 2.DBBL.

Universitäts-Sportclub Mainz (University Sports Club Mainz) is a German sports club based in Mainz (Germany). It was founded on 9 September 1959 by Berno Wischmann primarily for students of the University of Mainz. It is considered one of the most powerful Athletics Sports clubs in Germany. 50 athletes of USC have distinguished themselves in a half-century in club history at Olympic Games, World and European Championships. In particular in the decathlon dominated USC athletes for decades: Already at the European Championships in Budapest in 1966, Mainz won three (Werner von Moltke, Jörg Mattheis and Horst Beyer) all decathlon medals. In the all-time list of the USC, there are nine athletes who have achieved more than 8,000 points – at the head of Siegfried Wentz (8762 points in 1983) and Guido Kratschmer (1980 world record with 8667 points). The most successful athlete of the association is more fighter, sprinter and long jumper Ingrid Becker (Olympic champion in 1968 in the pentathlon and Olympic champion in 1972 in the 4 × 100 Metres Relay and European champion in 1971 in the long jump). The most famous athletes of the present are the sprinter Marion Wagner (world champion in 2001 in the 4 × 100 Metres Relay) and the pole vaulters Carolin Hingst (Eighth of the 2008 Olympics in Beijing) and Anna Battke.

Three world titles adorn the balance of USC Mainz. For the discus thrower, Lars Riedel attended (1991 and 1993) and the already mentioned sprinter Marion Wagner (2001). Added to 5 titles at the European Championships, a total of 65 international medals and 260 victories at the German Athletics Championships.

The players of USC's basketball section played from the season 1968/69 to the season 1974/75 in the National Basketball League (BBL) of the German Basketball Federation (DBB). As a finalist to winning the DBB Cup in 1971 USC Mainz played in the 1971–72 FIBA European Cup Winners' Cup against the Italian Cup winners of Fides Napoli.

The Baseball and Softball Club Mainz Athletics is a German baseball and softball club located in the city of Mainz in Rhineland-Palatinate. The Athletics is one of the largest clubs in the Baseball-Bundesliga Süd in terms of membership, claiming to have hundreds of active players. The club has played in the Baseball-Bundesliga for more than two decades and has won the German Championship in 2007 and 2016.

Mainz is documented to be a wine-growing region since bishop Boniface aquired a vineyard boardering the city wall and further vine platations in Bretzenheim in 752 and is one of the centres of the German wine industry. Since 2008, the city is a member of the Great Wine Capitals Global Network (GWC), an association of well-known wineculture-cities of the world. Many wine traders work in the city. The sparkling wine producer Kupferberg produced in Mainz-Hechtsheim and Henkell – now located on the other side of the river Rhine – were once founded in Mainz. The famous Blue Nun, one of the first branded wines, was marketed by the Sichel family. The Haus des Deutschen Weines (House of German Wine), is located in the city. The Mainzer Weinmarkt (wine market) is one of the great wine fairs in Germany.

The Schott AG, one of the world's largest glass manufactures, as well as the Werner & Mertz, a large chemical factory, are based in Mainz. Other companies such as IBM, QUINN Plastics, or Novo Nordisk have their German administration in Mainz as well. BioNTech, a biotechnology company developing immunotherapies including a vaccine against coronavirus disease 2019 (COVID-19) was founded in 2008 in Mainz by scientists Uğur Şahin, and Özlem Türeci, with the Austrian oncologist Christoph Huber.

Johann-Joseph Krug [de], founder of France's famous Krug champagne house in 1843, was born in Mainz in 1800.

Mainz is a major transport hub in southern Germany. It is an important component in European distribution, as it has the fifth largest inter-modal port in Germany. The Port of Mainz, now handling mainly containers, is a sizable industrial area to the north of the city, along the banks of the Rhine. In order to open up space along the city's riverfront for residential development, it was shifted further northwards in 2010.

Mainz Central Station or Mainz Hauptbahnhof, is frequented by 80,000 travelers and visitors each day and is therefore one of the busiest 21 stations in Germany. It is a stop for the S-Bahn line S8 of the Rhein-Main-Verkehrsverbund. Additionally, the Mainbahn line to Frankfurt Hbf starts at the station. It is served by 440 daily local and regional trains (StadtExpress, RE and RB) and 78 long-distance trains (IC, EC and ICE). Intercity-Express lines connect Mainz with Frankfurt (Main), Karlsruhe Hbf, Worms Hauptbahnhof and Koblenz Hauptbahnhof. It is a terminus of the West Rhine Railway and the Mainz–Ludwigshafen railway, as well as the Alzey–Mainz Railway erected by the Hessische Ludwigsbahn in 1871. Access to the East Rhine Railway is provided by the Kaiserbrücke, a railway bridge across the Rhine at the north end of Mainz.

The Mainz Central Station is an interchange point for the Mainz tramway network, and an important bus junction for the city and region (RNN, ORN and MVG).

Mainz offers a wide array of bicycle transportation facilities and events, including several miles of on-street bike lanes. The Rheinradweg (Rhine Cycle Route) is an international cycle route, running from the source to the mouth of the Rhine, traversing four countries at a distance of 1,300 km (810 mi). Another cycling tour runs towards Bingen and further to the Middle Rhine, a UNESCO World Heritage Site (2002).

Mainz is served by Frankfurt Airport, the busiest airport by passenger traffic in Germany by far, the third busiest in Europe and the ninth busiest worldwide in 2009. Located about 10 miles (16 kilometres) east of Mainz, it is connected to the city by an S-Bahn line.

The small Mainz Finthen Airport, located just 3 miles (5 km) southwest of Mainz, is used by general aviation only. Another airport, Frankfurt-Hahn Airport located about 50 miles (80 km) west of Mainz, is served by a few low-cost carriers.

• List of people related to Mainz
• Archbishops of Mainz
• List of mayors of Mainz

Mainz is twinned with:

• Johann Fust
• Johannes Gutenberg
• Peter Schöffer, apprentice of Gutenberg and early printer

• Hope, Valerie. Constructing Identity: The Roman Funerary Monuments of Aquelia, Mainz and Nîmes; British Archaeological Reports (16 July 2001) ISBN 978-1-84171-180-5
• Imhof, Michael and Simone Kestin: Mainz City and Cathedral Guide. Petersberg: Michael Imhof Verlag, 2004. ISBN 978-3-937251-93-6
• Mainz ("Vierteljahreshefte für Kultur, Politik, Wirtschaft, Geschichte"), since 1981
• Saddington, Denis. The stationing of auxiliary regiments in Germania Superior in the Julio-Claudian period
• Stanton, Shelby, World War II Order of Battle: An Encyclopedic Reference to U.S. Army Ground Forces from Battalion through Division, 1939–1946 (Revised Edition, 2006), Stackpole Books ISBN 978-0-8117-0157-0
• "Rede: UNESCO-Welterbe-Urkunde für die SchUM-Stätten". Der Bundespräsident (in German). Retrieved 1 February 2023.

Wikimedia Commons has media related to Mainz.

Wikivoyage has a travel guide for Mainz.

• Official website
• "Mainz" . Catholic Encyclopedia. 1913.
• "Mainz" . Encyclopædia Britannica. Vol. 17 (11th ed.). 1911. pp. 444–445.
• "Mainz" . Collier's New Encyclopedia. 1921.
• "ShUM Sites of Speyer, Worms and Mainz, Germany". Google Arts & Culture. Retrieved 31 January 2023.
• Duchhardt, Heinz (31 January 2023). ""Römer" in Mainz: Ein Doppelporträt aus der Frühgeschichte der "neuen" Mainzer Universität". Qfiab 94 (2014) (in German). 94: 292–310. Retrieved 31 January 2023.