Mambwe District is a district of Zambia, located in Eastern Province. Mambwe District inhabits the Luangwa Valley between the 13th and 14th parallel of south latitude. The Kunda name for this area is "Malambo''.

The land is bounded on the west by the Luangwa River, on the south by the Lusangazi River and on the north by the Chisitu River. It is approximately 700km east of Zambia’s capital city, Lusaka.

The capital lies at Mambwe named after the great leader of the Kunda people during their migration from the Congo.

The district is home of the world-renowned South Luangwa National Park, one of the greatest wildlife sanctuaries in the world.The district has one parliamentary constituency called Malambo Constituency. It is further divided into 15 wards namely: Chikowa, Chipako, Chipapa, Chisengu, Jumbe, Kakumbi, Kasamanda, Malama, Mdima, Mnkhanya, Mphomwa, Msoro, Ncheka, Nsefu and Nyakatokoli.

13°21′S 31°56′E / 13.350°S 31.933°E / -13.350; 31.933