Mandalay General Hospital (Burmese: မန္တလေးပြည်သူ့ဆေးရုံကြီး; abbreviated MGH) is a major teaching hospital in Mandalay, Myanmar, with a bed capacity of 1,500. It serves as the primary teaching institution for University of Medicine, Mandalay, alongside Mandalay Workers' Hospital. It is located on 30th Street, between 74th and 77th Streets in Chanayethazan Township. The hospital treats over 1,200 patients per day. The hospital is currently led by Dr Su Su Dwe.

Mandalay General Hospital was founded in 1887 by the British authorities as a civil medical establishment for Upper Burma.

In 2013, Mandalay General Hospital began a major expansion project, at a cost of US$2.88 million, to construct a 10-storey building to house an additional 500 beds. The building was inaugurated on 28 March 2015.

MGH maintains both medical and surgical specialist departments and diagnostic departments.