Mandromodromotra is a rural municipality in Madagascar. It belongs to the district of Taolanaro, which is a part of Anosy Region. The population of the commune was estimated to be approximately 4,000 in 2001 commune census.

Only primary schooling is available. The majority 50% of the population of the commune are farmers, while an additional 10% receives their livelihood from raising livestock. The most important crop is rice, while other important products are lychee, cassava and sweet potatoes. Industry and services provide employment for 2% and 3% of the population, respectively. Additionally fishing employs 35% of the population.

This municipality is crossed by the National road 12a, 17 km from Fort-Dauphin.

24°55′S 47°2′E / 24.917°S 47.033°E / -24.917; 47.033