Mary MacKillop Catholic Regional College is an independent Roman Catholic co-educational secondary school, located in Leongatha, Victoria, Australia. The college s services the South Gippsland parishes of Foster, Wonthaggi, Cowes, Korumburra and Leongatha.

The site of the college was purchased in the 1950s; at that stage students seeking a Catholic education had to travel to the Latrobe Valley or to boarding schools in Melbourne or elsewhere. A working party to establish the college began work in the late 1970s, and the school opened to its first students in 1986 on the grounds of a local primary school. The college moved to its permanent site in 1987 and the first permanent purpose-built buildings were constructed in 1989. Government funding and local fundraising have allowed several extensions to be constructed since then.

• Kaila McKnight – Australian representative to the 2012 Olympics in Athletics
• Angus McLaren – Australian actor who is best known for his roles in the television series Packed to the Rafters as Nathan Rafter and H₂O: Just Add Water as Lewis McCartney.
• Eleanor Patterson – gold medallist in High Jump at the 2014 Commonwealth Games