Matagalpa (Spanish pronunciation: [mataˈɣalpa]) is a department in central Nicaragua. It covers an area of 6,804 km and has a population of 600,057 (2021 est). The capital is the city of Matagalpa with a population of about 111,000.

Matagalpa is the second largest region of the country in population size, and the fifth in area (after the North Atlantic, the South Atlantic, Jinotega and Río San Juan).

Matagalpa is the most diversified region producing coffee, cattle, milk products, vegetables, wood, gold, flowers. Its extensive forests, rivers and geography are suited for ecotourism.

Although the Cacaopera people constitute the majority of the indigenous inhabitants in Matagalpa, the Nahua people inhabit the Sebaco valley, one of the most fertile areas in Nicaragua.

1. Ciudad Darío
2. Esquipulas
3. Matagalpa
4. Matiguás
5. Muy Muy
6. Rancho Grande
7. Río Blanco
8. San Dionisio
9. San Isidro
10. San Ramón
11. Sébaco
12. Terrabona
13. Tuma-La Dalia

• Portal del Norte de Nicaragua

12°55′N 85°55′W / 12.917°N 85.917°W / 12.917; -85.917