Matchi-Manitou is an unorganized territory in the Abitibi-Témiscamingue region of Quebec, Canada. It is one of five unorganized territories in La Vallée-de-l'Or Regional County Municipality.

Until July 6, 1996, Matchi-Manitou was a vast unorganized territory encompassing a land area of 16,760 km (6,470 sq mi). On that day, most of it was added to the City of Senneterre and a smaller portion to the City of Val-d'Or. It retained only two small non-contiguous areas, of which its eastern part is a section of land straddling both banks of the Chochocouane River and mostly part of the La Vérendrye Wildlife Reserve.

It is named after Matchi-Manitou Lake (48°00′45″N 77°02′56″W / 48.01250°N 77.04889°W / 48.01250; -77.04889), which used to be within its limits, but since 1996 is part of Senneterre and Val-d'Or. Its name is taken from both the Cree and Innu languages and means "evil spirit".

Population:

Historical census populations – Matchi-Manitou

Year Pop. ±% 1986 251 —     1991 240 −4.4% 1996 241 +0.4% 2001 0 −100.0%	Year Pop. ±% 2006 0 0.00% 2011 0 0.00% 2016 0 0.00% 2021 0 0.00%
Population counts are not adjusted for boundary changes. Source: Statistics Canada