The Mausoleum of Safavid Princes (Persian: آرامگاه شاهزادگان صفوی) is a historic funerary monument in the Chaharsu-ye-Kuchak district of Isfahan, Iran. It entombs the remains of some of the great-grandsons of Safavid ruler, Shah Ismail I who were executed during the reign of Shah Safi.

When Sam Mirza came to power as the new Shah of Iran and took the royal title of Shah Safi, he ruthlessly eliminated anyone he regarded as a threat to his power, executing almost all of the Safavid royal princes. Some of these murdered or executed princes were entombed between the years 1631 to 1632 at the spot where the mausoleum is now. The mausoleum was renovated in 1826 during the reign of Fath-Ali Shah Qajar. An inscribed poem, dating back to the same year, reveals a name of a "Muhammad Ali Khan" who was responsible for the renovations.

On the west of the mausoleum is the Tomb of Seti Fateme (Persian: آرامگاه ستی فاطمه) which is believed to contain the grave of Siti Fatimah, a daughter of the seventh Imam of Ahlulbayt, Musa al-Kadhim. This building dates back to the reign of Shah Abbas I. Despite the attribution, there is no historical evidence that a daughter of Musa al-Kadhim was buried there, nor is there any proof for her existence. There is a private mausoleum for the influential families of Soltan Khalifa and Sadat Marashi in this area as well.

• List of historical structures in Isfahan for a more comprehensive list on the historical sites in Isfahan, Iran
• List of mausoleums in Iran for a complete list of mausoleums in Iran