Mezzeh Air Base (also spelled Mazzeh) is a Syrian Air Force air base located in Mezzeh, Damascus, Syria, south-west of the old centre of Damascus. It has one runway of 8258 ft length, at elevation 2407 ft. In mid-2013 the airbase was described by the BBC as "an important strategic installation [which] plays a significant role in distributing the government's military supplies." Reuters reported in mid-2013 that it was "used by Syria's elite Republican Guards, Special Forces and Air Force Intelligence, [and] also serves as a private airport for the Assad family." It also said that during the Syrian civil war the base was "used to fire rockets and artillery at rebellious Sunni Muslim neighbourhoods on the edge of the capital." The location of the Mezzeh Air Base has also been used by the Syrian regime as a jail to imprison opponents during the Syrian civil war. Various inquiries and investigations reported that acts of torture and possible war crimes were committed in the jails of Mezzeh Air Base.

During World War II the Mazzeh airfield was a military base for the Vichy French air force, which also permitted Germany to use its bases. On 19 May 1941, British aircraft attacked the airfield, destroying some modern Potez 63 aircraft as well some older Potez 25 biplanes.

After Syrian independence in 1946, Mazzeh became a base for the Syrian Air Force. "By the end of 1957 the SAF had two operational MiG-17 squadrons defending the capital from their base at al-Mezze near Damascus." In 1966 it became also the Defense Companies Headquarter.

The airbase was subject to an attack that was blamed on Israel by Syrian authorities on January 13, 2017.

• List of Syrian Air Force bases