McCollum-Murray House, also known as the C. E. Murray House, is a historic home located at Greeleyville, Williamsburg County, South Carolina. Built c. 1906, the house was the home of African-American educator Dr. Charles Edward Murray, and is an example of transitional folk Victorian and Classical Revival residential architecture. It was originally a two-story, T-shaped dwelling. It features a wraparound one-story porch. It has a single-story rear gabled addition, with another single-story shed-roofed addition built in the 1950s.

It was listed in the National Register of Historic Places in 2006.