Archbishop McNicholas High School is a coed school in the neighborhood of Mt. Washington in Cincinnati, Ohio, USA. The school was opened in 1951 and named in honor of John T. McNicholas, Archbishop of Cincinnati.

In 1915, St. Joseph Academy, an all-girls academy, was opened as a day and boarding school operated by the Sisters of St. Joseph of Medaille. In 1950, Archbishop John T. McNicholas designated the academy would become the first co-ed parochial high school in Cincinnati. Archbishop McNicholas died before the school was opened and his successor, Archbishop Karl J. Alter approved on January 15, 1951, that the school be named for Archbishop McNicholas.

The school was purchased from the Sisters of Saint Joseph of Medaille by the Roman Catholic Archdiocese of Cincinnati in 1998.

The geographic district of Archbishop McNicholas High School is on the eastern side of Hamilton County and extends into Clermont and Brown Counties.

The curriculum is accredited by the Ohio Department of Education and the Ohio Catholic School Accrediting Association. 99% of the students attending McNicholas High School further their education in post-secondary schools and colleges. It is required that students have two semester-length theology classes every year at McNicholas, as well as community service hours.

The oldest building on the McNicholas campus is the St. Joseph Academy building, now called the Convent, which celebrated its 100th year of use in 2014. The building is home to business offices, a chapel, and the World Languages classrooms.

McNicholas High School's Penn Station Stadium was completed in the fall of 2018 as part of the "Paradise" athletic complex. The stadium features synthetic turf, an all-weather track, and a fixed seating capacity of 2,250, with additional capacity available throughout the concourse.

In addition to the stadium and track, McNicholas's "Paradise" is home to baseball and softball fields, a gymnasium, weight room, two additional practice fields, and a community pavilion.

• Men's soccer – 1984
• Baseball – 1998
• Men's Golf - 2016
• Women's Basketball – 2001
• Women's Soccer - 2014
• Men's Volleyball – 2024

• Men's Basketball (District)1974, 1981, 1983, 1984, 1985, 1991, 1992, 1993, 1995, 1998, 1999 (Regional) 1974, 1984, 1985, 1991, 1993, 1995
• Women's Basketball (District) 2001, 2002, 2003, 2007 (Regional) 2001
• Men's Volleyball (District) 2004, 2006, 2007, 2008, 2009, 2013, 2015, 2016 (Regional) 2008, 2014, 2016
• Women's Volleyball (District) 1975, 1976, 2003, 2004, 2005, 2006, 2007, 2012, 2013, 2014
• Women's soccer District 2013,2014,2016
• Men's Track and Field, Shot Put (District) 2022
• Men's Track and Field, 400m (District) 2022
• Men's Track and Field, 4x400m relay (Regional) 2022

• Girls Dance Team - 2008, 2009, 2011, 2013, 2016

Notable alumni include:

• Larry Cipa (1969) - football player (NFL)
• Kevin Huber (2004) - football player, Cincinnati Bengals
• Tom Mooney (1970) - educator, President of the Ohio Federation of Teachers
• Jean Schmidt (1970) - former US House Representative for the second district of Ohio.
• Pat Tabler (1976) - baseball player (MLB)
• Bob Wiesenhahn (1957) - basketball player (NBA and Cincinnati Bearcats - National Championship Team)