Meadow Grove Farm is a historic farm complex and national historic district located at Amissville, Rappahannock County, Virginia. It encompasses 13 contributing buildings and 5 contributing sites. The main house was constructed in four distinct building phases from about 1820 to 1965. The oldest section is a 1 1/2-story log structure, with a two-story Greek Revival style main block added about 1860. A two-story brick addition, built in 1965, replaced a two-story wing added in 1881. In addition to the main house the remaining contributing resources include a tenant house/slave quarters, a schoolhouse, a summer kitchen, a meat house, a machine shed, a blacksmith shop, a barn, a chicken coop, a chicken house, two granaries, and a corn crib; a cemetery, an icehouse ruin, two former sites of the present schoolhouse, and the original site of the log granary.

It was added to the National Register of Historic Places in 2006.