Medrese of Mehmet Şakir Paşa, also known as Madrasa of Mustafapaşa is a 19th-century madrasa, an Islamic educational institute, in Nevşehir Province, central Turkey. It is also known as a caravanserai.

The madrasa is in Mustafapaşa, formerly Sinasos, in Ürgüp District of Nevşehir Province.

It was built in 1890 by Mehmet Şakir Pasha in the town center. The building was also used as an imaret, a public soup kitchen, and during the Republican era, it was used as carpet market. It was restored in 1982. Currently, it houses a part of Kapodokya Undergraduate School.

It is a U-plan building. There is a seven-line inscription on the main gate. The students' quarters are behind the arched portico.