The Meherrin River is a 143.37 mi (230.73 km) long 6th order tributary to the Chowan River that joins in Hertford County, North Carolina.

A twenty-foot-high dam on the river creates a reservoir in Emporia. For most of its length, the Meherrin is not large enough for commercial traffic. It widens somewhat between Murfreesboro, North Carolina and the Chowan. Prior to the American Civil War, this section of the river was a significant trading route for Northeastern North Carolina.

The river was named after the Meherrin Indians, whose territory was along it.

According to the Geographic Names Information System, it has also been known historically as:

• Maherine River
• Maherrin River
• Mehearin River
• Meherin River
• Pochike River
• Wayanock
• Woodford River

The Meherrin River is formed at the confluence of the South Meherrin River and North Meherrin River at Reekes Mill, Virginia, and then flows southeasterly into North Carolina to join the Chowan River about 0.5 miles north of Chowan Beach in Hertford County, North Carolina.

The Meherrin River drains 1,601.05 square miles (4,146.7 km) of area, receives about 46.3 in/year of precipitation, has a wetness index of 495.22, and is about 46% forested.

• List of rivers of Virginia