Melincué is a town (comuna) in the south of the province of Santa Fe, Argentina, 287 km from the provincial capital. It has about 2,200 inhabitants as per the 2001 census [INDEC] and it is the head town of the General López Department. It was founded in 1872 and recognized officially as a town on 3 September 1986.

Melincué is located immediately north of an endorheic lake (Laguna Melincué) and an associated wetland area that is included in a nature reserve. The fluctuating level of the Melincué Lake and the lack of hydrical infrastructure have often caused the town to suffer floods.

• Municipal information: Municipal Affairs Federal Institute (IFAM), Municipal Affairs Secretariat, Ministry of Interior, Argentina. (in Spanish)
• "Melincué". Santa Fe provincial government.