Merseburg-Querfurt was a district (Kreis) in the south of Saxony-Anhalt, Germany. Neighboring districts were (from northwest clockwise) Sangerhausen, Mansfelder Land, Saalkreis, the district-free city Halle, the districts Delitzsch and Leipziger Land in Saxony, the districts Weißenfels and Burgenlandkreis, and the Kyffhäuserkreis in Thuringia.

The district was created in 1994 by merging the previous districts Merseburg and Querfurt.

The main river of the district is the Saale.

The cross in the top left and bottom right quarters of the coat of arms is the symbols of the diocese of Merseburg. The horizontal red-and-white bars in the other two quarters are the symbol of the Lords of Querfurt. The coat of arms thus combines the symbols of the two precursor districts.

Towns	Verwaltungsgemeinschaften	Free municipalities
Braunsbedra Leuna Querfurt	Bad Dürrenberg (incl. town Bad Dürrenberg) Bad Lauchstädt (incl. town Bad Lauchstädt) Kötzschau Laucha-Schwarzeiche (incl. town Schafstädt) Merseburg (incl. town Merseburg) Oberes Geiseltal (incl. town Mücheln) Weida-Land (incl. town Schraplau)	Schkopau

• Official website (German)

51°22′N 12°00′E / 51.367°N 12.000°E / 51.367; 12.000