Mescherin is a municipality in the Uckermark district, in Brandenburg, in north-eastern Germany. It is located on the western shore of the Oder river and the German-Polish border.

A road bridge links Mescherin with the Polish-Pomeranian town of Gryfino across the river. The nearest city is Szczecin, about 20 km (12 mi) to the north. Mescherin is located on the northern edge of Lower Oder Valley National Park.

On December 31, 2002, the municipalities of Neurochlitz, Radekow and Rosow were incorporated into Mescherin. In Rosow, a 13th-century church serves as a joint German-Polish memorial site for the flight and expulsion of Germans during and after World War II and the resettlement of Poles from Soviet-annexed eastern Polish territory into former eastern German provinces which became again Polish in 1945. Rosow was chosen as the Pomeranian village became a border checkpoint of both the federal highway Bundesstraße 2 and the Berlin-Szczecin railway.

Mescherin: Population development
within the current boundaries (2020)

Year Pop. ±% p.a. 1875 2,221 —     1890 1,950 −0.86% 1910 1,948 −0.01% 1925 1,711 −0.86% 1933 1,622 −0.67% 1939 1,630 +0.08% 1946 1,914 +2.32% 1950 1,982 +0.88% 1964 1,549 −1.75% 1971 1,460 −0.84% 1981 1,021 −3.51% 1985 964 −1.43% 1989 864 −2.70% 1990 856 −0.93% 1991 809 −5.49%

Year Pop. ±% p.a. 1992 821 +1.48% 1993 827 +0.73% 1994 859 +3.87% 1995 856 −0.35% 1996 848 −0.93% 1997 843 −0.59% 1998 824 −2.25% 1999 863 +4.73% 2000 857 −0.70% 2001 832 −2.92% 2002 809 −2.76% 2003 800 −1.11% 2004 785 −1.88% 2005 776 −1.15% 2006 778 +0.26%

Year Pop. ±% p.a. 2007 783 +0.64% 2008 777 −0.77% 2009 788 +1.42% 2010 785 −0.38% 2011 760 −3.18% 2012 791 +4.08% 2013 784 −0.88% 2014 795 +1.40% 2015 786 −1.13% 2016 802 +2.04% 2017 825 +2.87% 2018 825 +0.00% 2019 822 −0.36% 2020 820 −0.24%