Mestisko (Hungarian: Kishely, until 1899: Mesztyiszkó) is a village and municipality in Svidník District in the Prešov Region of north-eastern Slovakia.

In historical records the village was first mentioned in 1414.

The municipality lies at an altitude of 254 metres and covers an area of 11.057 km². It has a population of about 464 people.

• Media related to Mestisko at Wikimedia Commons
• Official website
• https://web.archive.org/web/20071027094149/http://www.statistics.sk/mosmis/eng/run.html