Miami–Erie Canal Site Historic District is a registered historic district on the Miami and Erie Canal near West Chester, Ohio. The district consists of Lock #38 on the canal, the house used by the lock's gatekeeper, and several foundation sites from demolished canal-related buildings. The limestone lock was built in 1825-26 as part of the original construction of the canal, which connected the Ohio River to Lake Erie. The gatekeeper's house, the second built at the lock, was constructed in 1870; the first house's foundation is still present as well. A mill race connects the lock to the former Friend and Fox Paper Company, which opened a paper mill on the canal in 1866. The paper mill was destroyed by a fire in 1932, though its foundations and retaining walls are still part of the site.

The district was added to the National Register of Historic Places on December 18, 1978.