The Midtown Historic District is a historic district in the city of Mobile, Alabama, United States. It was placed on the National Register of Historic Places on November 29, 2001, with a small boundary increase on November 18, 2020 It is roughly bounded by Taylor Avenue, Government Street, Houston Street, Kenneth Street, Springhill Avenue, and Florida Street. The district covers 467 acres (1.89 km) and contains 1,270 contributing buildings. The majority of the contributing buildings range in age from the 1880s to the 1950s and cover a wide variety of architectural styles. The district was significantly affected by a tornado on December 25, 2012.

• Contributing and individually NRHP-listed buildings to the Midtown Historic District
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  George Fearn House at 1806 Old Government Street
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  Wade Askew House at 103 Florence Place
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  Carlen House at 54 South Carlen Street
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  Murphy High School at 100 South Carlen Street
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  Trinity Episcopal Church at 1900 Dauphin Street
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  Termite Hall at 2000 Dauphin Street