Mierzączka Duża [mjɛˈʐɔnt͡ʂka ˈduʐa] is a village in the administrative district of Gmina Dłutów, within Pabianice County, Łódź Voivodeship, in central Poland. It lies approximately 6 kilometres (4 mi) west of Dłutów, 11 km (7 mi) south-west of Pabianice, and 27 km (17 mi) south-west of the regional capital Łódź.

The village has an approximate population of 190.