Mill Creek is an unincorporated community in Washington County, Texas, United States. According to the Handbook of Texas, the community had a population of 40 in 2000. It is located within the Greater Houston metropolitan area.

Mill Creek is located on Farm to Market Road 28 on the Southern Pacific Railroad, 3/4 of a mile from Lake Lange and 5.5 mi (8.9 km) from Brenham in southwestern Washington County.

Today, the community is served by the Brenham Independent School District.

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