Mindanao State University – Tawi-tawi College of Technology and Oceanography or (MSU-TCTO) is an autonomous campus of the Mindanao State University system located in Sanga-Sanga, Bongao, in the province of Tawi-Tawi, Philippines.

Starting in 1964 as Mindanao State University Preparatory High School in Bongao, Tawi-Tawi (a mere adjunct to MSU Marawi Preparatory High School), MSU Tawi-Tawi College of Technology and Oceanography has grown into an institution of academic excellence. More secondary schools were established from 1967 to 1977 in the outlying island municipalities of Tawi-Tawi. By 1990, 20 high schools were put up throughout the province. In 1984, MSU-TCTO Science High School and MSU-TCTO Child Development Center – Laboratory Elementary School were established.

Republic Act No. 6060 signed by President Ferdinand Marcos established the MSU-Sulu College of Technology and Oceanography on August 4, 1969, initially offering degree programs and diploma in Fisheries Technology.

On March 16, 1982, Batas Pambansa Blg. 197 was signed into law, changing the name of Sulu College of Technology and Oceanography into Tawi-Tawi College of Technology and Oceanography. It became part of the Mindanao State University System as an autonomous campus.