Mireșu Mare (Hungarian: Nagynyíres) is a commune in Maramureș County, northwestern Romania. It is located near Ulmeni, on the right, eastern bank of the river Someș. The commune is composed of seven villages: Dăneștii Chioarului (Dánfalva), Iadăra (Jeder), Lucăcești (Szamoslukácsi), Mireșu Mare, Remeți pe Someș (Gyökeres), Stejera (Jávorfalu), and Tulghieș (Szamostölgyes).

The commune belongs to the Baia Mare metropolitan area. It is located in the southwestern part of the Maramureș County, 29 km (18 mi) from the county seat, Baia Mare.

The Mireșu Mare train station serves the CFR Main Line 400, which connects Brașov with Baia Mare and Satu Mare.