Mission Hills is a neighborhood in Los Angeles, California, located in the San Fernando Valley.

It is near the northern junction of the Golden State Freeway (I-5) and the San Diego Freeway (I-405). The Ronald Reagan Freeway (SR-118) bisects the community. Mission Hills is at the northern end of the long Sepulveda Boulevard. Other main thoroughfares are San Fernando Mission Boulevard, Woodman Avenue, and Rinaldi, Brand, Chatsworth, Devonshire, and Lassen Streets. The boundaries are roughly Sepulveda Blvd and Interstate 405 to the west, Interstate 5 to the north and east, Van Nuys Boulevard to the southeast, and Lassen Street to the south. The Granada Hills community lies to the west, Sylmar to the north, the city of San Fernando to the northeast, Pacoima to the east, Arleta to the southeast, and Panorama City to the south.

The historical town was Hickson, now is named Mission Hills for the nearby Spanish Mission San Fernando Rey de España (1784). It includes the Andrés Pico Adobe, the second oldest residence still standing in Los Angeles. The San Fernando Mission Cemetery, located a short distance away, is one of the oldest active cemeteries within the San Fernando Valley.

The 2010 U.S. census counted 18,496 residents in the area's 91345 ZIP Code. The median age was 36.3, and the median yearly household income at that time was $62,426.

In 2009, the Los Angeles Times's "Mapping L.A." project supplied the following numbers for the community of Mission Hills. Population: 18,237; median household income: $75,675. Mexican (41.3%) and German (4.4%) were the most common ancestries. Mexico (45.7%) and El Salvador (11.5%) were the most common foreign places of birth.

Residents are zoned to schools in the Los Angeles Unified School District. Mission Hills has one private school within its boundaries; Bishop Alemany High School which is run by the Archdiocese of Los Angeles.

The community is serviced by Providence Holy Cross Medical Center, Facey Medical Group, and a newly opened Kaiser Permanente.

The United States Postal Service operates the Mission City Post Office at 10919 Sepulveda Boulevard.

The Los Angeles County Department of Health Services operates the Pacoima Health Center in Pacoima, serving Mission Hills.

In May 2005, the Los Angeles Police Mission Area was established as the 19th station built in the City of Los Angeles. This police station serves the communities of Mission Hills, Sylmar, North Hills, Arleta, and Panorama City.

The City of Los Angeles Fire Department provides fire and emergency medical services from Station 75. This consists of two engines (E75 & E275), a ladder truck (T75), and both an advanced life support ambulance (Rescue 75) and a basic life support ambulance (Rescue 875).

• Mission Hills is represented in the United States Senate by California's Senators Laphonza Butler and Alex Padilla.
• The community of Mission Hills is located within California's 29th congressional district represented by Democrat Tony Cárdenas.

Mission Hills is located within California's 39th State Assembly district represented by Democrat Luz Rivas and California's 18th State Senate district represented by Democrat Robert Hertzberg.

Mission Hills is located within Los Angeles City Council District 7 represented by Monica Rodriguez.

Tourists visit the Mission San Fernando Rey de España, a historical mission. The Andrés Pico Adobe is the second-oldest adobe home in the city of Los Angeles.

People who were born in Mission Hills include:

• Ryan Braun (major league baseball All Star and MVP outfielder)
• Jessica Cosby (Olympic athlete; track and field)
• Michael Kuluva (fashion designer)
• George Lopez (comedian)
• Scott McAfee (actor)

34°15′26″N 118°28′02″W / 34.257222°N 118.467222°W / 34.257222; -118.467222