Mission San Diego station is a station on San Diego Trolley's Green Line. The elevated station has side platforms. It is located in the Grantville neighborhood near Mission San Diego de Alcalá and National University's San Diego campus.

From the station's opening in late 1997, this station was the former terminus for the Blue Line trolleys until the July 2005 introduction of the Green Line service, in conjunction with the opening of the Mission Valley East extension, pushed the Blue Line's terminus back to Old Town Transit Center.

With the Blue Line's truncation, all Green Line trolleys now serve the former portion of the Blue Line from Old Town to this station and points eastward. (A system redesign on September 2, 2012, truncated the Blue Line's terminus farther to America Plaza station and extended the Green Line's terminus from Old Town to 12th & Imperial Transit Center.)

There are two tracks, each served by a side platform.

Side platform, doors will open on the right
Westbound	← Green Line toward 12th & Imperial (Fenton Parkway)
Eastbound	→ Green Line toward El Cajon (Grantville) →
Side platform, doors will open on the right

• List of San Diego Trolley stations