The U.S. state of Mississippi's at-large congressional district existed from December 10, 1817, when it was admitted to the Union until 1847, when representatives were elected in districts.

Mississippi briefly elected an at-large representative from 1853 to 1855, in addition to having the rest of the delegation elected from districts.

Cong ress	Years		Seat A				Seat B				Seat C				Seat D
			Representative	Party	Electoral history		Representative	Party	Electoral history		Representative	Party	Electoral history		Representative	Party	Electoral history
15th	December 10, 1817		District created
	December 10, 1817 – March 3, 1819		George Poindexter (Woodville)	Democratic-Republican	Elected in 1817. Retired.		No 2nd seat				No 3rd seat				No 4th seat
16th	March 4, 1819 – March 3, 1821		Christopher Rankin (Natchez)	Democratic-Republican	Elected in 1819. Re-elected in 1820. Re-elected in 1822. Re-elected in 1824. Died.
17th	March 4, 1821 – March 3, 1823
18th	March 4, 1823 – March 3, 1825
19th	March 4, 1825 – March 14, 1826			Jacksonian
	March 14, 1826 – July 10, 1826		Vacant
	July 10, 1826 – March 3, 1827		William Haile (Woodville)	Jacksonian	Elected July 11, 1826 to finish Rankin's term and seated December 4, 1826. Re-elected later in 1826. Resigned.
20th	March 4, 1827 – July 10, 1828
	July 10, 1828 – October 21, 1828		Vacant
	October 21, 1828 – March 3, 1829		Thomas Hinds (Greenville)	Jacksonian	Elected October 20, 1828 to finish Haile's term and seated December 8, 1828. Elected August 4–5, 1828 to the next term. Retired.
21st	March 3, 1829 – March 3, 1831
22nd	March 4, 1831 – March 3, 1833		Franklin E. Plummer (Westville)	Jacksonian	Elected in 1830. Re-elected in 1832. Retired to run for U.S. senator.
23rd	March 4, 1833 – March 3, 1835						Harry Cage (Woodville)	Jacksonian	Elected in 1832. Retired.
24th	March 4, 1835 – July 31, 1836		John F. H. Claiborne (Madisonville)	Jacksonian	Elected in 1835. Re-elected in 1837 but election was invalidated.		David Dickson (Jackson)	Anti-Jacksonian	Elected in 1835. Died.
	July 31, 1836 – January 7, 1837						Vacant
	January 7, 1837 – March 3, 1837						Samuel J. Gholson (Athens)	Jacksonian	Elected November 7, 1836 to finish Dickson's term and seated January 7, 1837. Re-elected in 1837 but election was invalidated.
25th	March 4, 1837 – July 17, 1837		Vacant				Vacant
	July 18, 1837 – February 5, 1838		John F. H. Claiborne (Madisonville)	Democratic	Credentials presented but election successfully contest and seat declared vacant.		Samuel J. Gholson (Athens)	Democratic	Credentials presented but election successfully contest and seat declared vacant.
	February 5, 1838 – May 29, 1838		Vacant				Vacant
	May 29, 1838 – March 3, 1839		Seargent S. Prentiss (Vicksburg)	Whig	Elected to finish Claiborne's term. Retired.		Thomas J. Word (Pontotoc)	Whig	Elected to finish Gholson's term. Retired.
26th	March 4, 1839 – March 3, 1841		Jacob Thompson (Oxford)	Democratic	Elected in 1839. Re-elected in 1841. Re-elected in 1843. Re-elected in 1845. Redistricted to the 1st district.		Albert G. Brown (Gallatin)	Democratic	Elected in 1839. Retired.
27th	March 4, 1841 – March 3, 1843						William M. Gwin (Vicksburg)	Democratic	Elected in 1841. Renominated but declined.
28th	March 4, 1843 – March 3, 1845						William H. Hammett (Princeton)	Democratic	Elected in 1843. Retired.		Robert W. Roberts (Hillsboro)	Democratic	Elected in 1843. Re-elected in 1845. Redistricted to the 3rd district and lost re-election..		Tilghman Tucker (Columbus)	Democratic	Elected in 1843. Retired.
29th	March 4, 1845 – June 1846						Stephen Adams (Aberdeen)	Democratic	Elected in 1845. Retired.						Jefferson Davis (Warrenton)	Democratic	Elected in 1845. Resigned to command regiment in Mexican–American War.
	June 1846 – January 26, 1847														Vacant
	January 26, 1847 – March 3, 1847														Henry T. Ellett (Port Gibson)	Democratic	Elected to finish Davis's term. Retired.
29th	March 4, 1847 – March 3, 1849		No at-large seats. Starting with the 1847 election, Mississippi elected all its representatives in districts until 1853.
31st	March 4, 1849 – March 3, 1851
32nd	March 4, 1851 – March 3, 1853
33rd	March 4, 1853 – March 3, 1855		William Barksdale (Columbus)	Democratic	Elected in 1853. Redistricted to the 3rd district.	In 1852, one representative was elected at-large, the remainder from districts.

• Martis, Kenneth C. (1989). The Historical Atlas of Political Parties in the United States Congress. New York: Macmillan Publishing Company.
• Martis, Kenneth C. (1982). The Historical Atlas of United States Congressional Districts. New York: Macmillan Publishing Company.
• Congressional Biographical Directory of the United States 1774–present
• "Our Campaigns - United States - Mississippi - MS - At Large". www.ourcampaigns.com. Retrieved May 20, 2020.

32°47′01″N 89°36′41″W / 32.783745°N 89.611309°W / 32.783745; -89.611309